Last reviewed · How we verify
lignocaine+bicarbonate
Lignocaine provides local anesthesia by blocking sodium channels in nerve fibers, while bicarbonate buffers the solution to reduce pain on injection and improve anesthetic efficacy.
Lignocaine provides local anesthesia by blocking sodium channels in nerve fibers, while bicarbonate buffers the solution to reduce pain on injection and improve anesthetic efficacy. Used for Local and regional anesthesia for surgical and dental procedures, Pain relief during minor medical procedures.
At a glance
| Generic name | lignocaine+bicarbonate |
|---|---|
| Sponsor | Aligarh Muslim University |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lignocaine (lidocaine) is a local anesthetic that reversibly inhibits sodium influx into nerve cells, preventing depolarization and blocking nerve conduction. The addition of sodium bicarbonate raises the pH of the solution, which increases the proportion of non-ionized lignocaine that can penetrate nerve tissue more readily, thereby accelerating onset and improving efficacy while reducing injection pain.
Approved indications
- Local and regional anesthesia for surgical and dental procedures
- Pain relief during minor medical procedures
Common side effects
- Injection site pain or burning
- Transient paresthesia
- Allergic reactions (rare with lignocaine)
- Systemic toxicity (if absorbed in excess)
Key clinical trials
- Bladder Directed vs. Pelvic Floor Therapy in IC/BPS (PHASE2)
- Comparison of Changes in Intra-myocardial Amino Acids During Use of Calafiore and Modified Del Nido Cardioplegia
- Buffered Lidocaine for Reducing Pain in Patients Undergoing Prostate Biopsy, BURN Trial (PHASE1, PHASE2)
- The Effect of Local Anesthesia Techniques on Postoperative Pain After Laser Treatment of Pilonidal Sinus (NA)
- Bicarbonate Addition to Lidocaine-Epinephrine in Surgery Under WALANT (PHASE4)
- WALANT Versus Local Anesthesia in Central Venous Catheter Insertion (NA)
- Ringer Acetate Based Modified Del Nido Cardioplegia Solution Versus HTK Solution Cardioplegia Solution in Cardiac Surgery (PHASE3)
- The Effectiveness of Intracuff Dexmedetomidine in Preventing Postoperative Sore Throat Following Prone Surgery (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- lignocaine+bicarbonate CI brief — competitive landscape report
- lignocaine+bicarbonate updates RSS · CI watch RSS
- Aligarh Muslim University portfolio CI