Last reviewed · How we verify
Lidocaine Ropivacaine
This combination of lidocaine and ropivacaine blocks sodium channels in nerve cell membranes to produce local anesthesia.
This combination of lidocaine and ropivacaine blocks sodium channels in nerve cell membranes to produce local anesthesia. Used for Local infiltration anesthesia, Regional anesthesia and nerve blocks, Topical/infiltrative anesthesia for surgical and dental procedures.
At a glance
| Generic name | Lidocaine Ropivacaine |
|---|---|
| Also known as | Naropin, Ropivacaine HCL |
| Sponsor | TriHealth Inc. |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Both lidocaine and ropivacaine are amide-type local anesthetics that work by inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, thereby preventing depolarization and conduction of action potentials. This dual-agent formulation combines the rapid onset of lidocaine with the longer duration of action and reduced systemic toxicity profile of ropivacaine. The combination is used to provide extended local anesthetic coverage for infiltration and regional anesthesia procedures.
Approved indications
- Local infiltration anesthesia
- Regional anesthesia and nerve blocks
- Topical/infiltrative anesthesia for surgical and dental procedures
Common side effects
- Injection site reactions (pain, erythema)
- Systemic toxicity (CNS effects: dizziness, tinnitus, seizures)
- Cardiovascular effects (hypotension, arrhythmias)
- Allergic reactions
Key clinical trials
- OMT for Adhesive Capsulitis (PHASE4)
- Mid-transverse Process Combined With Erector Spinae Block Versus Paravertebral Plane Block (NA)
- Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty (PHASE4)
- PAravertebral CaTheter Versus Epidural Analgesia in Totally Minimally Invasive Esophagectomies (NA)
- Comparison of SPSIP Block and SAP Block in Non-Intubated Uniportal VATS. (NA)
- Tubeless Strategy in Lung Transplantation: A Prospective Single-Arm Study (NA)
- Dexamethasone as ESPB Adjuvant in Lumbar Laminectomy (PHASE3)
- Comparison of Systemic Opioid (Morphine) and Pre-Incision Bilateral Scalp Nerve Block for Pain Management in Craniotomy Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |