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Lidocaine infiltration
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia.
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Local infiltration anesthesia for minor surgical procedures, Pain relief during wound closure and tissue manipulation.
At a glance
| Generic name | Lidocaine infiltration |
|---|---|
| Sponsor | Vrije Universiteit Brussel |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in nerve fibers. This prevents depolarization and the generation of action potentials, thereby blocking nerve conduction in the infiltrated tissue. When injected locally, it produces reversible loss of sensation in the area of administration.
Approved indications
- Local infiltration anesthesia for minor surgical procedures
- Pain relief during wound closure and tissue manipulation
Common side effects
- Local tissue irritation or burning at injection site
- Systemic toxicity (CNS effects: tremor, confusion, seizures) at high doses
- Cardiovascular effects (hypotension, arrhythmias) at high doses
- Allergic reactions (rare with amide lidocaine)
Key clinical trials
- Predictors of Treatment Response to Stellate Ganglion Block in Cervical Radicular Pain
- Pain Experience Using Lidocaine Adrenaline Tetracaine (LAT) Gel Versus Lidocaine Infiltration for Laceration Repair in Adults (PHASE4)
- Efficacy and Safety of Combined Nanofat Injection With Either Platelet Rich Fibrin or Microneedling Versus Nanofat Injection Alone in the Treatment of Facial Atrophic Post Acne Scars (NA)
- Mid-transverse Process Combined With Erector Spinae Block Versus Paravertebral Plane Block (NA)
- Combination of Fluoroscopy and Ultrasonography Guidance in Sacroiliac Joint Injections. A Randomised Controlled Trial (NA)
- Functional Outcomes After LumbOpenitoneal Shunt Placement UndeR Local Anesthesia for Patients With Idiopathic Normal preSsure Hydrocephalus (FLOURISH) Trial (PHASE4)
- Thoracic Epidural Analgesia With Bilateral Erector Spinae Plane Block in Radical Cystectomy Surgery (NA)
- PAravertebral CaTheter Versus Epidural Analgesia in Totally Minimally Invasive Esophagectomies (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lidocaine infiltration CI brief — competitive landscape report
- Lidocaine infiltration updates RSS · CI watch RSS
- Vrije Universiteit Brussel portfolio CI