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Lidocaine Hydrochloride Preservative Free (Lidocaine Hydrochloride)
Lidocaine Hydrochloride Preservative Free (generic name: Lidocaine Hydrochloride) is a Local anesthetic (amide class) Small molecule drug developed by Pfizer Inc.. It is currently FDA-approved for Topical anesthesia of irritated mucous membranes of the mouth, Topical anesthesia of inflamed mucous membranes of the mouth, Topical anesthesia of irritated mucous membranes of the pharynx.
Lidocaine Hydrochloride is a preservative-free topical anesthetic marketed by Pfizer for local anesthesia of oral and pharyngeal mucous membranes. It functions as a sodium channel blocker, preventing nerve impulse transmission in localized areas. The formulation is indicated for reducing discomfort during dental procedures, X-ray imaging, and management of irritated oral tissues. As a well-established local anesthetic, it offers rapid onset and predictable efficacy for short-duration procedures. The preservative-free formulation enhances safety profile for sensitive patients and frequent users.
At a glance
| Generic name | Lidocaine Hydrochloride |
|---|---|
| Sponsor | Pfizer Inc. |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels (Nav) |
| Modality | Small molecule |
| Phase | FDA-approved |
Approved indications
- Topical anesthesia of irritated mucous membranes of the mouth
- Topical anesthesia of inflamed mucous membranes of the mouth
- Topical anesthesia of irritated mucous membranes of the pharynx
- Topical anesthesia of inflamed mucous membranes of the pharynx
- Reducing gagging during X-ray picture taking
- Reducing gagging during dental impression taking
Boxed warnings
- WARNING: Life-threatening and fatal events in infants and young children Postmarketing cases of seizures, cardiopulmonary arrest, and death in patients under the age of 3 years have been reported with use of Lidocaine Viscous 2% when it was not administered in strict adherence to the dosing and administration recommendations. In the setting of teething pain, Lidocaine Viscous 2% should generally not be used. For other conditions, the use of the product in patients less than 3 years of age should be limited to those situations where safer alternatives are not available or have been tried but failed. To decrease the risk of serious adverse events with use of Lidocaine Viscous 2%, instruct caregivers to strictly adhere to the prescribed dose and frequency of administration and store the prescription bottle safely out of reach of children.
Common side effects
- Lightheadedness
- Nervousness
- Apprehension
- Euphoria
- Confusion
- Dizziness
- Drowsiness
- Tinnitus
- Blurred or double vision
- Vomiting
- Twitching
- Tremors
Drug interactions
- nitroglycerin
- nitroprusside
- nitric oxide
- nitrous oxide
- benzocaine
- lidocaine
- bupivacaine
- mepivacaine
- tetracaine
- prilocaine
- procaine
- articaine
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- OMT for Adhesive Capsulitis (PHASE4)
- Sphenopalatine Ganglion Block for Post-Dural Puncture Headache: A Pilot Randomised Controlled Trial (NA)
- The Analgesic Efficacy and Safety of Venlafaxine for Prevention of Postherpetic Neuralgia in Patients With Acute Herpes Zoster (NA)
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial (PHASE3)
- USG-Guided Shoulder Injections in Frozen Shoulder (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lidocaine Hydrochloride Preservative Free CI brief — competitive landscape report
- Lidocaine Hydrochloride Preservative Free updates RSS · CI watch RSS
- Pfizer Inc. portfolio CI
Frequently asked questions about Lidocaine Hydrochloride Preservative Free
What is Lidocaine Hydrochloride Preservative Free?
Lidocaine Hydrochloride Preservative Free (Lidocaine Hydrochloride) is a Local anesthetic (amide class) drug developed by Pfizer Inc., indicated for Topical anesthesia of irritated mucous membranes of the mouth, Topical anesthesia of inflamed mucous membranes of the mouth, Topical anesthesia of irritated mucous membranes of the pharynx.
What is Lidocaine Hydrochloride Preservative Free used for?
Lidocaine Hydrochloride Preservative Free is indicated for Topical anesthesia of irritated mucous membranes of the mouth, Topical anesthesia of inflamed mucous membranes of the mouth, Topical anesthesia of irritated mucous membranes of the pharynx, Topical anesthesia of inflamed mucous membranes of the pharynx, Reducing gagging during X-ray picture taking.
Who makes Lidocaine Hydrochloride Preservative Free?
Lidocaine Hydrochloride Preservative Free is developed and marketed by Pfizer Inc. (see full Pfizer Inc. pipeline at /company/pfizer).
What is the generic name of Lidocaine Hydrochloride Preservative Free?
Lidocaine Hydrochloride is the generic (nonproprietary) name of Lidocaine Hydrochloride Preservative Free.
What drug class is Lidocaine Hydrochloride Preservative Free in?
Lidocaine Hydrochloride Preservative Free belongs to the Local anesthetic (amide class) class. See all Local anesthetic (amide class) drugs at /class/local-anesthetic-amide-class.
What development phase is Lidocaine Hydrochloride Preservative Free in?
Lidocaine Hydrochloride Preservative Free is FDA-approved (marketed).
What are the side effects of Lidocaine Hydrochloride Preservative Free?
Common side effects of Lidocaine Hydrochloride Preservative Free include Lightheadedness, Nervousness, Apprehension, Euphoria, Confusion, Dizziness.
What does Lidocaine Hydrochloride Preservative Free target?
Lidocaine Hydrochloride Preservative Free targets Voltage-gated sodium channels (Nav) and is a Local anesthetic (amide class).
Related
- Drug class: All Local anesthetic (amide class) drugs
- Target: All drugs targeting Voltage-gated sodium channels (Nav)
- Manufacturer: Pfizer Inc. — full pipeline
- Indication: Drugs for Topical anesthesia of irritated mucous membranes of the mouth
- Indication: Drugs for Topical anesthesia of inflamed mucous membranes of the mouth
- Indication: Drugs for Topical anesthesia of irritated mucous membranes of the pharynx
- Compare: Lidocaine Hydrochloride Preservative Free vs similar drugs
- Pricing: Lidocaine Hydrochloride Preservative Free cost, discount & access