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Lignospan Forte (Lidocaine Hydrochloride)

Fresenius Kabi · FDA-approved approved Small molecule Quality 68/100

Lignospan Forte (generic name: Lidocaine Hydrochloride) is a local anesthetic, amide type Small molecule drug developed by Fresenius Kabi. It is currently FDA-approved (first approved 1948) for Hemorrhoids, Infestation by Phthirus pubis, Infestation by Sarcoptes scabiei var hominis.

Lidocaine stabilizes neuronal membrane by inhibiting ionic fluxes required for impulse initiation and conduction.

Lidocaine Hydrochloride (Lignospan Forte) is a topical amide-type local anesthetic indicated for anesthesia of irritated or inflamed mucous membranes of the mouth and pharynx. It stabilizes neuronal membranes by inhibiting ionic fluxes required for impulse conduction, with rapid hepatic metabolism and renal excretion. Contraindicated in patients with hypersensitivity to amide-type local anesthetics; concurrent use with methemoglobinemia-inducing drugs increases risk of this serious adverse effect. When used at recommended dosages, the drug produces modest hypotension and is useful for reducing gagging during dental and radiographic procedures.

At a glance

Generic name	Lidocaine Hydrochloride
Sponsor	Fresenius Kabi
Drug class	local anesthetic, amide type
Target	neuronal membrane ionic channels
Modality	Small molecule
Phase	FDA-approved
First approval	1948

Mechanism of action

Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Excessive blood levels may cause changes in cardiac output, total peripheral resistance, and mean arterial pressure, attributable to a direct depressant effect on various cardiovascular system components. The net effect is normally a modest hypotension when recommended dosages are not exceeded.

Approved indications

Hemorrhoids
Infestation by Phthirus pubis
Infestation by Sarcoptes scabiei var hominis
Itching of skin
Local Anesthesia for Endotracheal Intubation
Local Anesthesia for Ophthalmologic Procedure
Local Anesthesia for Urethral Pain
Local anesthesia
Local anesthetic intrathecal block
Minor Skin Wound Pain
Mouth Irritation
Neuralgia
Pediculosis capitis
Postherpetic neuralgia
Premature ejaculation
Prevent Minor Bacterial Skin Infection
Pruritus ani
Regional Anesthesia for Ophthalmologic Surgery
Skin irritation
Suppression of the Gag Reflex

Boxed warnings

For external use onlyAvoid contact with eyes and mucous memberanesDo not bandage tightly. Avoid contact with eyes and mucous memberanes. Do not bandage tightly.

Common side effects

Dizziness
Constipation
Procedural pain
Headache
Arrhythmia
Nausea
Itching
Diarrhoea
Vomiting
Gastroenteritis
Incision site pain
Sensory disturbance

Drug interactions

Nitrates/Nitrites (nitroglycerin, nitroprusside, nitric oxide, nitrous oxide)
Local anesthetics (benzocaine, bupivacaine, mepivacaine, tetracaine, prilocaine, procaine, articaine, ropivacaine)
Antineoplastic agents (cyclophosphamide, flutamide, rasburicase, ifosfamide, hydroxyurea)
Antibiotics (dapsone, sulfonamides, nitrofurantoin, para-aminosalicylic acid)
Antimalarials (chloroquine, primaquine)
Anticonvulsants (phenytoin, sodium valproate, phenobarbital)
Other drugs (acetaminophen, metoclopramide, sulfasalazine, quinine)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
FDA label	Mechanism, indications, dosing, boxed warnings, drug interactions

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Lignospan Forte CI brief — competitive landscape report
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Fresenius Kabi portfolio CI

Frequently asked questions about Lignospan Forte

What is Lignospan Forte?

Lignospan Forte (Lidocaine Hydrochloride) is a local anesthetic, amide type drug developed by Fresenius Kabi, indicated for Hemorrhoids, Infestation by Phthirus pubis, Infestation by Sarcoptes scabiei var hominis.

How does Lignospan Forte work?

Lidocaine stabilizes neuronal membrane by inhibiting ionic fluxes required for impulse initiation and conduction.

What is Lignospan Forte used for?

Lignospan Forte is indicated for Hemorrhoids, Infestation by Phthirus pubis, Infestation by Sarcoptes scabiei var hominis, Itching of skin, Local Anesthesia for Endotracheal Intubation.

Who makes Lignospan Forte?

Lignospan Forte is developed and marketed by Fresenius Kabi (see full Fresenius Kabi pipeline at /company/pfizer).

What is the generic name of Lignospan Forte?

Lidocaine Hydrochloride is the generic (nonproprietary) name of Lignospan Forte.

What drug class is Lignospan Forte in?

Lignospan Forte belongs to the local anesthetic, amide type class. See all local anesthetic, amide type drugs at /class/local-anesthetic-amide-type.

When was Lignospan Forte approved?

Lignospan Forte was first approved on 1948.

What development phase is Lignospan Forte in?

Lignospan Forte is FDA-approved (marketed).

What are the side effects of Lignospan Forte?

Common side effects of Lignospan Forte include Dizziness, Constipation, Procedural pain, Headache, Arrhythmia, Nausea.

What does Lignospan Forte target?

Lignospan Forte targets neuronal membrane ionic channels and is a local anesthetic, amide type.

Drug class: All local anesthetic, amide type drugs
Target: All drugs targeting neuronal membrane ionic channels
Manufacturer: Fresenius Kabi — full pipeline
Indication: Drugs for Hemorrhoids
Indication: Drugs for Infestation by Phthirus pubis
Indication: Drugs for Infestation by Sarcoptes scabiei var hominis
Compare: Lignospan Forte vs similar drugs
Pricing: Lignospan Forte cost, discount & access