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Lidocaine HCl 1%
Lidocaine HCl blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.
Lidocaine HCl blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Local anesthesia for infiltration, nerve blocks, and topical application, Pain relief in minor surgical and dental procedures.
At a glance
| Generic name | Lidocaine HCl 1% |
|---|---|
| Also known as | ESRACAIN, Lidocaine, Dynexan Mundgel®, Xylocaine, Lidocaine Viscous |
| Sponsor | HaEmek Medical Center, Israel |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by reversibly inhibiting sodium influx through voltage-gated sodium channels in the neuronal cell membrane. This prevents depolarization and the generation of action potentials, thereby blocking pain signal transmission. At 1% concentration, it is suitable for infiltration anesthesia, topical application, and regional anesthesia procedures.
Approved indications
- Local anesthesia for infiltration, nerve blocks, and topical application
- Pain relief in minor surgical and dental procedures
Common side effects
- Injection site reactions (pain, erythema)
- Systemic toxicity (CNS effects: dizziness, tremor, seizures at high doses)
- Cardiovascular effects (hypotension, arrhythmias at high doses)
- Allergic reactions (rare with amide local anesthetics)
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- OMT for Adhesive Capsulitis (PHASE4)
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- USG-Guided Shoulder Injections in Frozen Shoulder (NA)
- Jaw Muscle Pain Post Wisdom Molar Surgery (PHASE2)
- Comparison of the Effectiveness of Exercise, Dry Needling and Interfascial Block Treatments in the Treatment of Myofascial Pain Syndrome (NA)
- Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy (PHASE4)
- Bladder Directed vs. Pelvic Floor Therapy in IC/BPS (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lidocaine HCl 1% CI brief — competitive landscape report
- Lidocaine HCl 1% updates RSS · CI watch RSS
- HaEmek Medical Center, Israel portfolio CI