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LIDOCAINE 1 %
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Local anesthesia for infiltration, nerve blocks, and topical application, Pain relief during minor surgical and dental procedures.
At a glance
| Generic name | LIDOCAINE 1 % |
|---|---|
| Also known as | XYLOCAINE |
| Sponsor | Ain Shams Maternity Hospital |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through sodium-selective channels in the nerve cell membrane, thereby preventing depolarization and blocking the generation and propagation of action potentials. This reversible blockade of nerve conduction results in loss of sensation in the area where it is applied or injected. The effect is localized and temporary, wearing off as the drug is metabolized and redistributed.
Approved indications
- Local anesthesia for infiltration, nerve blocks, and topical application
- Pain relief during minor surgical and dental procedures
Common side effects
- Localized reactions (erythema, edema, burning at injection site)
- Systemic toxicity (tremors, dizziness, seizures) with overdose
- Allergic reactions (rare with amide lidocaine)
- Methemoglobinemia (with topical spray formulations)
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- Closed Versus Open Lateral Internal Sphincterotomy for Chronic Anal Fissure (NA)
- OMT for Adhesive Capsulitis (PHASE4)
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- USG-Guided Shoulder Injections in Frozen Shoulder (NA)
- Jaw Muscle Pain Post Wisdom Molar Surgery (PHASE2)
- Comparison of the Effectiveness of Exercise, Dry Needling and Interfascial Block Treatments in the Treatment of Myofascial Pain Syndrome (NA)
- Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- LIDOCAINE 1 % CI brief — competitive landscape report
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- Ain Shams Maternity Hospital portfolio CI