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Lidocaïne

University Hospital, Angers · FDA-approved active Small molecule

Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials and thereby producing local anesthesia.

Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia. Used for Local anesthesia for infiltration, nerve block, and topical use, Ventricular arrhythmias (intravenous formulation), Topical pain relief.

At a glance

Generic nameLidocaïne
SponsorUniversity Hospital, Angers
Drug classLocal anesthetic
TargetVoltage-gated sodium channels
ModalitySmall molecule
Therapeutic areaAnesthesia / Pain Management
PhaseFDA-approved

Mechanism of action

Lidocaine is a local anesthetic that works by reversibly inhibiting sodium influx through voltage-gated sodium channels in nerve fibers. This prevents depolarization and the generation of action potentials, effectively blocking nerve conduction in the area where it is applied or injected. It has a rapid onset and intermediate duration of action, making it suitable for both infiltration anesthesia and topical application.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results