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Levofloxacin + dexamethasone followed by dexamethasone
Levofloxacin + dexamethasone followed by dexamethasone is a Fluoroquinolone antibiotic + corticosteroid combination Small molecule drug developed by NTC srl. It is currently in Phase 3 development for Bacterial infection with associated inflammation (specific indication not publicly detailed for this Phase 3 trial). Also known as: Levofloxacin + dexamethasone followed by Maxidex.
Levofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, while dexamethasone is a corticosteroid that suppresses inflammation and immune responses.
Levofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, while dexamethasone is a corticosteroid that suppresses inflammation and immune responses. Used for Bacterial infection with associated inflammation (specific indication not publicly detailed for this Phase 3 trial).
At a glance
| Generic name | Levofloxacin + dexamethasone followed by dexamethasone |
|---|---|
| Also known as | Levofloxacin + dexamethasone followed by Maxidex |
| Sponsor | NTC srl |
| Drug class | Fluoroquinolone antibiotic + corticosteroid combination |
| Target | Bacterial DNA gyrase, topoisomerase IV (levofloxacin); glucocorticoid receptor (dexamethasone) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Immunology |
| Phase | Phase 3 |
Mechanism of action
Levofloxacin works by inhibiting bacterial DNA replication and transcription through topoisomerase inhibition, effectively killing susceptible bacteria. Dexamethasone, administered sequentially, reduces inflammation and immune-mediated tissue damage that may accompany or follow infection. This combination approach targets both the infectious agent and the inflammatory response.
Approved indications
- Bacterial infection with associated inflammation (specific indication not publicly detailed for this Phase 3 trial)
Common side effects
- Tendinopathy
- QT prolongation
- Hyperglycemia
- Immunosuppression
- Gastrointestinal disturbance
Key clinical trials
- Dextenza in the Post-op Management of Vitreoretinal Surgeries (PHASE4)
- Pain and Microbial Reduction of Antimicrobial Corticosteroid Mixture Versus Cryotherapy in Necrotic Teeth (NA)
- Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (PHASE3)
- Prospective Study on DEXTENZA® Safety And Efficacy Following Concomitant MIGS and Cataract Surgery (PHASE4)
- Levo-Dexa vs. Tobra+Dexa for Prevention and Treatment of Inflammation and Prevention of Infection in Cataract Surgery (PHASE3)
- Early Changes Among FLEx, LASIK and FS-LASIK (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Levofloxacin + dexamethasone followed by dexamethasone CI brief — competitive landscape report
- Levofloxacin + dexamethasone followed by dexamethasone updates RSS · CI watch RSS
- NTC srl portfolio CI
Frequently asked questions about Levofloxacin + dexamethasone followed by dexamethasone
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Related
- Drug class: All Fluoroquinolone antibiotic + corticosteroid combination drugs
- Target: All drugs targeting Bacterial DNA gyrase, topoisomerase IV (levofloxacin); glucocorticoid receptor (dexamethasone)
- Manufacturer: NTC srl — full pipeline
- Therapeutic area: All drugs in Infectious Disease / Immunology
- Indication: Drugs for Bacterial infection with associated inflammation (specific indication not publicly detailed for this Phase 3 trial)
- Also known as: Levofloxacin + dexamethasone followed by Maxidex
- Compare: Levofloxacin + dexamethasone followed by dexamethasone vs similar drugs
- Pricing: Levofloxacin + dexamethasone followed by dexamethasone cost, discount & access