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Levobupivacaine continuous infusion
Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Regional anesthesia via continuous infusion, Postoperative pain management via continuous peripheral nerve block.
At a glance
| Generic name | Levobupivacaine continuous infusion |
|---|---|
| Also known as | continuous infusion group |
| Sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Levobupivacaine is the S-enantiomer of bupivacaine, a long-acting amide local anesthetic. It works by reversibly inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, thereby preventing depolarization and nerve impulse transmission. When administered as a continuous infusion, it provides prolonged regional anesthesia or analgesia at the infusion site.
Approved indications
- Regional anesthesia via continuous infusion
- Postoperative pain management via continuous peripheral nerve block
Common side effects
- Systemic toxicity (CNS effects: tremor, seizures)
- Cardiovascular effects (hypotension, arrhythmias)
- Local site reactions (erythema, edema)
- Allergic reactions
Key clinical trials
- PENG Block: Continuous Infusion vs. Programmed Intermittent Bolus in Neck of Femur Fracture (NA)
- Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery (PHASE4)
- The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks (NA)
- Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery (PHASE4)
- Rebound Pain Following Regional Anaesthesia for Ankle Fracture Surgery (PHASE4)
- Mid-point to Pleura Transverse Process Block Versus Thoracic Intervertebral Foramen Block (NA)
- Optimal Postoperative Pain Management After Lung Surgery (OPtriAL) (NA)
- PIEB-PCEA Versus CEI-PCEA for Labor Analgesia in Nulliparous (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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