Last reviewed · How we verify
L-Leucine (LEUCINE)
L-Leucine works by binding to a specific transporter in the body that helps regulate the uptake of amino acids.
L-Leucine is a small molecule leucine that targets the Large neutral amino acids transporter small subunit 1. Its mechanism of action is not well-documented, and it is not FDA-approved for any indications. As a result, there is limited information available on its commercial status, safety considerations, or pharmacokinetic properties. Further research is needed to fully understand the potential benefits and risks of L-Leucine. Its development status and ownership are also unclear.
At a glance
| Generic name | LEUCINE |
|---|---|
| Drug class | leucine |
| Target | Large neutral amino acids transporter small subunit 1 |
| Modality | Small molecule |
| Therapeutic area | Other |
| Phase | discontinued |
Mechanism of action
CLINIMIX is used as supplement of nutrition in patients, providing macronutrients (amino acids and dextrose) parenterally.The amino acids provide the structural units that make up proteins and are used to synthesize proteins and other biomolecules or are oxidized to urea and carbon dioxide as source of energy.The administered dextrose is oxidized to carbon dioxide and water, yielding energy.
Approved indications
Common side effects
- Metabolic acidosis
- Alkalosis
- Osmotic diuresis and dehydration
- Rebound hypoglycemia
- Hypo- and hyper-vitaminosis
- Pulmonary embolism due to pulmonary vascular precipitates
- Hypersensitivity reactions
- Risk of Infections
- Refeeding syndrome
- Hyperglycemia or hyperosmolar hyperglycemic state
- Vein damage and thrombosis
- Hepatobiliary disorders
Key clinical trials
- The Acute Effects of Onnit Alpha Brain on Cognition and Mood States (NA)
- Pivotal Study of N-acetyl-L-leucine for CACNA1A (PHASE3)
- Pre-Surgical Immunonutrition's Effect on Colorectal Surgery (NA)
- N-Acetyl-L-Leucine for Ataxia-Telangiectasia (A-T) (PHASE2)
- Leucine Requirements in School-Age Children (NA)
- How Animal and Plant Protein Shakes Change the Body's Nutrient and Health Responses (NA)
- Eucine-Restricted Diet in Gastric Cancer Patients (PHASE1)
- Protein Supplement and Exercise Training for the Treatment of Sarcopenia Risk in Older Adults (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |