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Letrozole or Anastrozole Tablets
Letrozole or Anastrozole Tablets is a Aromatase inhibitor Small molecule drug developed by Jiangsu HengRui Medicine Co., Ltd.. It is currently in Phase 3 development for Hormone receptor-positive, HER2-negative breast cancer in postmenopausal women (adjuvant or metastatic), Extended adjuvant therapy following tamoxifen in postmenopausal women with early-stage breast cancer.
Letrozole and Anastrozole are aromatase inhibitors that block the conversion of androgens to estrogen, reducing estrogen levels in postmenopausal women with hormone receptor-positive breast cancer.
Letrozole and Anastrozole are aromatase inhibitors that block the conversion of androgens to estrogen, reducing estrogen levels in postmenopausal women with hormone receptor-positive breast cancer. Used for Hormone receptor-positive, HER2-negative breast cancer in postmenopausal women (adjuvant or metastatic), Extended adjuvant therapy following tamoxifen in postmenopausal women with early-stage breast cancer.
At a glance
| Generic name | Letrozole or Anastrozole Tablets |
|---|---|
| Sponsor | Jiangsu HengRui Medicine Co., Ltd. |
| Drug class | Aromatase inhibitor |
| Target | Aromatase (CYP19A1) |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Both drugs inhibit the aromatase enzyme, which catalyzes the final step of estrogen synthesis in postmenopausal women. By depleting circulating estrogen levels, they suppress the growth of estrogen-dependent breast cancer cells. These are non-steroidal aromatase inhibitors commonly used as first-line endocrine therapy for hormone receptor-positive breast cancer.
Approved indications
- Hormone receptor-positive, HER2-negative breast cancer in postmenopausal women (adjuvant or metastatic)
- Extended adjuvant therapy following tamoxifen in postmenopausal women with early-stage breast cancer
Common side effects
- Hot flashes
- Arthralgia/joint pain
- Fatigue
- Headache
- Nausea
- Osteoporosis/bone loss
- Vaginal dryness
Key clinical trials
- A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence (PHASE3)
- A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer (PHASE3)
- Phase 2 Study of Amcenestrant (SAR439859) Versus Physician's Choice in Locally Advanced or Metastatic ER-positive Breast Cancer (PHASE2)
- A Study of Changes in Ki67 Expression in People With Breast Cancer Receiving Endocrine Therapy Before Surgery (NA)
- A Phase 3 Study of HRS-8080 Versus Treatment Chosen by Physicians in Locally Advanced and Metastatic Breast Cancer (PHASE3)
- Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6) (PHASE3)
- PreOperative Endocrine Therapy for Individualised Care With Abemaciclib (PHASE3)
- Ovarian Suppression Evaluating Subcutaneous Leuprolide Acetate in Breast Cancer (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Letrozole or Anastrozole Tablets CI brief — competitive landscape report
- Letrozole or Anastrozole Tablets updates RSS · CI watch RSS
- Jiangsu HengRui Medicine Co., Ltd. portfolio CI
Frequently asked questions about Letrozole or Anastrozole Tablets
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Related
- Drug class: All Aromatase inhibitor drugs
- Target: All drugs targeting Aromatase (CYP19A1)
- Manufacturer: Jiangsu HengRui Medicine Co., Ltd. — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Hormone receptor-positive, HER2-negative breast cancer in postmenopausal women (adjuvant or metastatic)
- Indication: Drugs for Extended adjuvant therapy following tamoxifen in postmenopausal women with early-stage breast cancer
- Compare: Letrozole or Anastrozole Tablets vs similar drugs
- Pricing: Letrozole or Anastrozole Tablets cost, discount & access