Last reviewed 2026-04-23 · How we verify

Lasosamide Oral Solution

Lasosamide enhances slow inactivation of voltage-gated sodium channels, thereby stabilizing neuronal membranes and reducing seizure activity.

Lasosamide enhances slow inactivation of voltage-gated sodium channels, thereby stabilizing neuronal membranes and reducing seizure activity. Used for Adjunctive treatment of partial-onset seizures in epilepsy.

At a glance

Mechanism of action

Lasosamide binds to voltage-gated sodium channels and selectively enhances their slow inactivation phase, which reduces repetitive neuronal firing and prevents seizure propagation. This mechanism differs from traditional sodium channel blockers by specifically targeting the slow inactivation process rather than fast inactivation, potentially offering improved tolerability. The drug is used as an adjunctive antiepileptic agent.

Approved indications

• Adjunctive treatment of partial-onset seizures in epilepsy

Common side effects

• Dizziness
• Headache
• Diplopia (double vision)
• Nausea
• Ataxia
• Blurred vision

Key clinical trials

• A Study to Assess the Safety and Efficacy of Lacosamide Versus Placebo (a Pill Without Active Medication) in Patients With Idiopathic Generalised Epilepsy Who Are Already Taking Anti-epileptic Medications (PHASE3)

Primary sources

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