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LAROPIPRANT
Laropiprant is a marketed drug primarily indicated for dyslipidemia, with a key composition patent expiring in 2028. Its mechanism of action, blocking prostaglandin D2, differentiates it from competitors targeting similar pathways. The primary risk is the competitive landscape, including off-patent drugs like alprostadil and dinoprostone, as well as patent-protected options such as epoprostenol, iloprost, and selexipag.
At a glance
| Generic name | LAROPIPRANT |
|---|---|
| Drug class | laropiprant |
| Target | Prostaglandin D2 receptor |
| Modality | Small molecule |
| Therapeutic area | Metabolic |
| Phase | FDA-approved |
Approved indications
- Dyslipidemia
Common side effects
Key clinical trials
- Efficacy and Safety of Extended Release (ER) Niacin/Laropiprant When Added to Ongoing Lipid-Modifying Therapy in Patients With High Cholesterol or Abnormal Lipid Levels (MK-0524A-133) (PHASE3)
- Lipid Efficacy of the Extended Release Niacin/Laropiprant Combination in Patients With Cardiovascular Disease (PHASE4)
- Effect of Tredaptive on Serum Lipoproteins and Inflammatory Markers (PHASE4)
- A Study to Evaluate the Effects of Extended Release (ER) Niacin/Laropiprant, Laropiprant, ER Niacin, and Placebo on Urinary Prostanoid Metabolites in Subjects With High Cholesterol (0524A-075)(COMPLETED) (PHASE1)
- ER Niacin/Laropiprant Impact on Cardiovascular Markers and Atheroprogression in HIV-infected Individuals on cART (PHASE4)
- Effect of Nicotinic Acid on Cardiovascular Risks Indices in Polycystic Ovary Syndrome (PHASE4)
- MK-0524B Lipid Study (MK-0524B-063) (PHASE3)
- Efficacy and Safety of Extended-Release Niacin/ Laropiprant/Simvastatin Tablets in Participants With Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-143) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- LAROPIPRANT CI brief — competitive landscape report
- LAROPIPRANT updates RSS · CI watch RSS