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Lactobacillus Rhamnosus
Lactobacillus Rhamnosus is a Live biotherapeutic / Probiotic Small molecule drug developed by Chang Gung Memorial Hospital. It is currently FDA-approved for Gastrointestinal disorders and microbiota modulation, Immune support and infection prevention. Also known as: Culturelle Kids.
Lactobacillus rhamnosus is a probiotic bacterium that modulates the gut microbiota and enhances intestinal barrier function and immune tolerance.
Lactobacillus Rhamnosus is a type of probiotic bacteria that has been studied for its potential benefits in gastrointestinal health, including symptoms of gastrointestinal disease, intestinal dysbiosis, and colorectal cancer. It is classified as a probiotic modality, according to ChEMBL, and has been used in combination with prebiotics and postbiotics in dietary supplements, such as Ritual Synbiotic+, to support overall health.
At a glance
| Generic name | Lactobacillus Rhamnosus |
|---|---|
| Also known as | Culturelle Kids |
| Sponsor | Chang Gung Memorial Hospital |
| Drug class | Live biotherapeutic / Probiotic |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology / Immunology |
| Phase | FDA-approved |
Mechanism of action
This live biotherapeutic produces short-chain fatty acids and other metabolites that strengthen the intestinal epithelial barrier, reduce pathogenic bacterial overgrowth, and promote regulatory T cell differentiation. It also produces antimicrobial compounds and competes with harmful bacteria for nutrients and adhesion sites in the gut, thereby reducing systemic inflammation and supporting immune homeostasis.
Approved indications
- Gastrointestinal disorders and microbiota modulation
- Immune support and infection prevention
Common side effects
- Gastrointestinal symptoms (bloating, gas, mild diarrhea)
- Allergic reactions (rare)
Key clinical trials
- Effects of Probiotics on Respiratory Tract Infections in Children: A Randomized, Placebo-Controlled Interventional Study (PHASE2)
- Effectiveness and Safety of Lactobacillus Rhamnosus Lcr35® in the Treatment of Recurrent Aphthous Stomatitis (PHASE2)
- Probiotic (LGG) for Veterans With PTSD (PHASE2)
- Impact of Supplementation With Synbiotics and Prebiotics on Cognitive Decline Associated With Neoadjuvant Chemotherapy in First-line Patients With Breast Cancer (NA)
- Modulation of Gut Microbiota Composition and Gut Permeability Profiles by Multispecies Synbiotic Supplementation in Hemodialysis Patients (NA)
- The Effect of Peri-Operative Adjunctive Probiotics on Immunological Markers in Cases of Prosthetic Joint Infection of the Hip and Knee (NA)
- Alterations of Gut Derived Uremic Toxins and Microbiome Metabolites by Multispecies Synbiotic (NA)
- Synbiotic Supplementation and Inflammation in Predialysis Chronic Kidney Disease (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lactobacillus Rhamnosus CI brief — competitive landscape report
- Lactobacillus Rhamnosus updates RSS · CI watch RSS
- Chang Gung Memorial Hospital portfolio CI
Frequently asked questions about Lactobacillus Rhamnosus
What is Lactobacillus Rhamnosus?
How does Lactobacillus Rhamnosus work?
What is Lactobacillus Rhamnosus used for?
Who makes Lactobacillus Rhamnosus?
Is Lactobacillus Rhamnosus also known as anything else?
What drug class is Lactobacillus Rhamnosus in?
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Related
- Drug class: All Live biotherapeutic / Probiotic drugs
- Manufacturer: Chang Gung Memorial Hospital — full pipeline
- Therapeutic area: All drugs in Gastroenterology / Immunology
- Indication: Drugs for Gastrointestinal disorders and microbiota modulation
- Indication: Drugs for Immune support and infection prevention
- Also known as: Culturelle Kids
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing