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Lactobacillus plantarum strain 299
Lactobacillus plantarum strain 299 is a probiotic bacterium that modulates the gut microbiome and intestinal barrier function to support immune homeostasis.
Lactobacillus plantarum strain 299 is a probiotic bacterium that modulates the gut microbiome and intestinal barrier function to support immune homeostasis. Used for Prevention or mitigation of chemotherapy-induced gastrointestinal toxicity in pediatric cancer patients, Support of immune recovery and reduction of infection risk in hematopoietic stem cell transplant recipients.
At a glance
| Generic name | Lactobacillus plantarum strain 299 |
|---|---|
| Also known as | DSM 6595, LACTOBACILLUS PLANTARUM 299 |
| Sponsor | Children's Oncology Group |
| Drug class | Live biotherapeutic product / Probiotic |
| Modality | Biologic |
| Therapeutic area | Oncology / Immunology |
| Phase | Phase 3 |
Mechanism of action
This live biotherapeutic product colonizes the gastrointestinal tract and produces metabolites that strengthen the intestinal epithelial barrier, reduce pathogenic bacterial translocation, and promote regulatory T cell differentiation. By restoring eubiotic conditions and enhancing mucosal immunity, it may reduce treatment-related toxicities and support immune recovery in cancer patients undergoing chemotherapy or hematopoietic stem cell transplantation.
Approved indications
- Prevention or mitigation of chemotherapy-induced gastrointestinal toxicity in pediatric cancer patients
- Support of immune recovery and reduction of infection risk in hematopoietic stem cell transplant recipients
Common side effects
- Gastrointestinal disturbance
- Bacteremia (rare, in immunocompromised patients)
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lactobacillus plantarum strain 299 CI brief — competitive landscape report
- Lactobacillus plantarum strain 299 updates RSS · CI watch RSS
- Children's Oncology Group portfolio CI