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Labetalol, Nifedipine
This combination of a non-selective beta-blocker (labetalol) and a calcium channel blocker (nifedipine) reduces blood pressure through dual inhibition of cardiac contractility and vascular smooth muscle contraction.
This combination of a non-selective beta-blocker (labetalol) and a calcium channel blocker (nifedipine) reduces blood pressure through dual inhibition of cardiac contractility and vascular smooth muscle contraction. Used for Hypertension management in pregnancy or hypertensive emergency (Phase 3 context suggests maternal/obstetric indication).
At a glance
| Generic name | Labetalol, Nifedipine |
|---|---|
| Also known as | Procardia, Trandate, Normodyne |
| Sponsor | Medical College of Wisconsin |
| Drug class | Combination antihypertensive (beta-blocker + calcium channel blocker) |
| Target | Alpha-1 adrenergic receptor, Beta-1 adrenergic receptor, Beta-2 adrenergic receptor, L-type calcium channel |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Labetalol blocks alpha-1, beta-1, and beta-2 adrenergic receptors, reducing heart rate and contractility while causing vasodilation. Nifedipine blocks L-type calcium channels in vascular smooth muscle, causing direct vasodilation. Together, they provide complementary antihypertensive effects with potentially synergistic blood pressure reduction.
Approved indications
- Hypertension management in pregnancy or hypertensive emergency (Phase 3 context suggests maternal/obstetric indication)
Common side effects
- Dizziness
- Fatigue
- Headache
- Hypotension
- Bradycardia
- Flushing
Key clinical trials
- Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
- Safest Choice of Antihypertensive Regimen for Postpartum Hypertension (PHASE3)
- Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study (NA)
- Preeclampsia Postpartum Antihypertensive Treatment (PHASE3)
- Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project (PHASE1)
- Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy
- PEACE Trial: Postpartum Evaluation of Antihypertensive Cessation and Efficacy (PHASE4)
- Postpartum Hypertension Study (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Labetalol, Nifedipine CI brief — competitive landscape report
- Labetalol, Nifedipine updates RSS · CI watch RSS
- Medical College of Wisconsin portfolio CI