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L-acetyl carnitine
L-acetyl carnitine facilitates the transport of long-chain fatty acids into mitochondria for β-oxidation, thereby enhancing cellular energy production.
L-acetyl carnitine facilitates the transport of long-chain fatty acids into mitochondria for β-oxidation, thereby enhancing cellular energy production. Used for Age-related cognitive decline, Peripheral neuropathy, Cardiac dysfunction.
At a glance
| Generic name | L-acetyl carnitine |
|---|---|
| Sponsor | University of Campania Luigi Vanvitelli |
| Drug class | Amino acid derivative / Metabolic agent |
| Target | Carnitine palmitoyltransferase (CPT) system |
| Modality | Small molecule |
| Therapeutic area | Neurology, Cardiology, Metabolic disorders |
| Phase | FDA-approved |
Mechanism of action
L-acetyl carnitine is an acetylated form of the amino acid carnitine that plays a critical role in mitochondrial fatty acid metabolism. It acts as a carrier molecule that transports activated long-chain fatty acids across the inner mitochondrial membrane, enabling their oxidation to generate ATP. This mechanism supports cellular energy metabolism and has been investigated for conditions characterized by impaired energy production or mitochondrial dysfunction.
Approved indications
- Age-related cognitive decline
- Peripheral neuropathy
- Cardiac dysfunction
- Fatigue and energy metabolism disorders
Common side effects
- Gastrointestinal upset
- Nausea
- Headache
- Insomnia
Key clinical trials
- The Effects of Acetyl-L-Carnitine and Myo/Chiro-Inositol in Patients With PCOS (NA)
- Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS (PHASE2, PHASE3)
- Enhancing the Effects of Alcohol Treatment With L-Carnitine (PHASE1)
- Pilot Study: Impact of Biomarker-Guided Dietary Supplementation on Quality-of-Life Measures in Subjects With Chronic Pain (PHASE2)
- Clinical Trial to Evaluate Safety and Efficacy of Jalosome® Soothing Gel. (NA)
- Independent and Additive Effects Of Micronutrients With Metformin In Patients With PCOS (NA)
- To Evaluate the Efficacy and Safety of HSK16149 With L-carnitine in Diabetic Peripheral Neuralgia Patients in China (NA)
- Combined Rehabilitation With ALA, ALC, Resveratrol and Vitamin D in Discogenic Sciatica in Young People (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- L-acetyl carnitine CI brief — competitive landscape report
- L-acetyl carnitine updates RSS · CI watch RSS
- University of Campania Luigi Vanvitelli portfolio CI