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KetoNaph
KetoNaph is a topical nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce inflammation and pain in the eye.
KetoNaph is a topical nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce inflammation and pain in the eye. Used for Postoperative inflammation and pain following cataract surgery, Postoperative inflammation and pain following refractive surgery.
At a glance
| Generic name | KetoNaph |
|---|---|
| Sponsor | Bausch & Lomb Incorporated |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | COX-1, COX-2 |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | Phase 3 |
Mechanism of action
KetoNaph works by blocking COX-1 and COX-2 enzymes in ocular tissues, thereby reducing the production of prostaglandins that mediate inflammation, pain, and other inflammatory responses. As a topical ophthalmic formulation, it delivers the active ingredient directly to the eye to manage postoperative inflammation and pain following cataract surgery and other ocular procedures.
Approved indications
- Postoperative inflammation and pain following cataract surgery
- Postoperative inflammation and pain following refractive surgery
Common side effects
- Ocular irritation
- Conjunctival hyperemia
- Corneal effects (including keratitis)
- Stinging or burning upon instillation
Key clinical trials
- Ketotifen/Naphazoline Ophthalmic Solution in the Conjunctival Allergen Challenge Model of Allergic Conjunctivitis. (PHASE3)
- Ketotifen/Naphazoline Ophthalmic Solution in the Conjunctival Allergen Challenge Model of Acute Allergic Conjunctivitis. (PHASE3)
- Study Evaluating the Safety of KetoNaph Ophthalmic Solution in Healthy Volunteers (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- KetoNaph CI brief — competitive landscape report
- KetoNaph updates RSS · CI watch RSS
- Bausch & Lomb Incorporated portfolio CI