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Ketamine , Lidocaine , Dexmedetomidine
Ketamine , Lidocaine , Dexmedetomidine is a Anesthetic combination / Sedative-analgesic combination Small molecule drug developed by University of Saskatchewan. It is currently in Phase 3 development for Anesthesia and analgesia (Phase 3 investigational combination). Also known as: Opioid-free pre-intubation medications.
This is a fixed-dose combination of three agents that work synergistically: ketamine blocks NMDA receptors for anesthesia/analgesia, lidocaine blocks sodium channels for local anesthesia, and dexmedetomidine activates alpha-2 adrenergic receptors for sedation and analgesia.
This is a fixed-dose combination of three agents that work synergistically: ketamine blocks NMDA receptors for anesthesia/analgesia, lidocaine blocks sodium channels for local anesthesia, and dexmedetomidine activates alpha-2 adrenergic receptors for sedation and analgesia. Used for Anesthesia and analgesia (Phase 3 investigational combination).
At a glance
| Generic name | Ketamine , Lidocaine , Dexmedetomidine |
|---|---|
| Also known as | Opioid-free pre-intubation medications |
| Sponsor | University of Saskatchewan |
| Drug class | Anesthetic combination / Sedative-analgesic combination |
| Target | NMDA receptor (ketamine), voltage-gated sodium channels (lidocaine), alpha-2 adrenergic receptors (dexmedetomidine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology / Pain Management |
| Phase | Phase 3 |
Mechanism of action
Ketamine provides dissociative anesthesia and analgesia through non-competitive NMDA receptor antagonism. Lidocaine provides local anesthetic effects via sodium channel blockade. Dexmedetomidine enhances sedation and analgesia through selective alpha-2 adrenergic receptor agonism, reducing the required doses of other agents while providing sympathomimetic stability. The combination is designed to provide balanced anesthesia with reduced individual drug requirements.
Approved indications
- Anesthesia and analgesia (Phase 3 investigational combination)
Common side effects
- Dissociation/emergence reactions
- Hypotension
- Bradycardia
- Respiratory depression
- Dizziness
Key clinical trials
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- Cardiac Index and General Anesthesia Without Opioid. (PHASE2, PHASE3)
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- Transition From Acute to Chronic Opioid Use and Chronic Pain (EARLY_PHASE1)
- General Anesthesia Versus Sedation By Dexmedetomidine and Ketamine With Local Infiltration for Percutaneous Transcatheter Closure of Atrial Septal Defect in Pediatric Patients (NA)
- Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery (NA)
- COMPARISON OF OPIOID-FREE AND OPIOID-BASED ANESTHESIA TECHNIQUES ON qNOX INDEX IN ABDOMINAL SURGERY UNDER GENERAL ANESTHESIA (NA)
- Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ketamine , Lidocaine , Dexmedetomidine CI brief — competitive landscape report
- Ketamine , Lidocaine , Dexmedetomidine updates RSS · CI watch RSS
- University of Saskatchewan portfolio CI
Frequently asked questions about Ketamine , Lidocaine , Dexmedetomidine
What is Ketamine , Lidocaine , Dexmedetomidine?
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What is Ketamine , Lidocaine , Dexmedetomidine used for?
Who makes Ketamine , Lidocaine , Dexmedetomidine?
Is Ketamine , Lidocaine , Dexmedetomidine also known as anything else?
What drug class is Ketamine , Lidocaine , Dexmedetomidine in?
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Related
- Drug class: All Anesthetic combination / Sedative-analgesic combination drugs
- Target: All drugs targeting NMDA receptor (ketamine), voltage-gated sodium channels (lidocaine), alpha-2 adrenergic receptors (dexmedetomidine)
- Manufacturer: University of Saskatchewan — full pipeline
- Therapeutic area: All drugs in Anesthesiology / Pain Management
- Indication: Drugs for Anesthesia and analgesia (Phase 3 investigational combination)
- Also known as: Opioid-free pre-intubation medications
- Compare: Ketamine , Lidocaine , Dexmedetomidine vs similar drugs
- Pricing: Ketamine , Lidocaine , Dexmedetomidine cost, discount & access