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Ketamine + Lidocaine
Ketamine blocks NMDA receptors while lidocaine provides local anesthetic effects, together modulating pain signaling and potentially enhancing anesthetic efficacy.
Ketamine blocks NMDA receptors while lidocaine provides local anesthetic effects, together modulating pain signaling and potentially enhancing anesthetic efficacy. Used for Anesthesia and analgesia (Phase 3 investigational).
At a glance
| Generic name | Ketamine + Lidocaine |
|---|---|
| Sponsor | State University of New York at Buffalo |
| Drug class | NMDA receptor antagonist + local anesthetic combination |
| Target | NMDA receptor; voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia; Pain Management |
| Phase | Phase 3 |
Mechanism of action
Ketamine is a non-competitive NMDA receptor antagonist that produces dissociative anesthesia and analgesia by blocking excitatory glutamatergic neurotransmission. Lidocaine is a local anesthetic that blocks sodium channels, inhibiting nerve conduction. The combination may provide synergistic analgesic and anesthetic effects with potentially reduced side effects compared to either agent alone.
Approved indications
- Anesthesia and analgesia (Phase 3 investigational)
Common side effects
- Dissociation
- Dizziness
- Nausea
- Local injection site reactions
Key clinical trials
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- Cardiac Index and General Anesthesia Without Opioid. (PHASE2, PHASE3)
- Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass (NA)
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- Transition From Acute to Chronic Opioid Use and Chronic Pain (EARLY_PHASE1)
- The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain. (EARLY_PHASE1)
- General Anesthesia Versus Sedation By Dexmedetomidine and Ketamine With Local Infiltration for Percutaneous Transcatheter Closure of Atrial Septal Defect in Pediatric Patients (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ketamine + Lidocaine CI brief — competitive landscape report
- Ketamine + Lidocaine updates RSS · CI watch RSS
- State University of New York at Buffalo portfolio CI