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ketamine + clonidine
Ketamine acts as an NMDA receptor antagonist, while clonidine is an alpha-2 adrenergic receptor agonist.
Ketamine acts as an NMDA receptor antagonist, while clonidine is an alpha-2 adrenergic receptor agonist. Used for Treatment-resistant depression.
At a glance
| Generic name | ketamine + clonidine |
|---|---|
| Sponsor | Irmandade da Santa Casa de Misericordia de Sao Paulo |
| Target | NMDA receptor, alpha-2 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | Phase 3 |
Mechanism of action
Ketamine's mechanism of action involves blocking the NMDA receptor, which is involved in the transmission of pain signals. Clonidine, on the other hand, works by stimulating alpha-2 adrenergic receptors, which can help reduce sympathetic nervous system activity and lower blood pressure.
Approved indications
- Treatment-resistant depression
Common side effects
- Dizziness
- Dry mouth
- Hypotension
Key clinical trials
- Premedication in Children: a Clinical Trial Comparing Oral Ketamine and Oral Clonidine With Respect to Sedation Level and Opioid Consumption in Pediatrics Undergoing Elective Lower Abdominal Day-case Surgery. (NA)
- Nociception Level During Opioid-sparing Anaesthesia Versus Conventional Opioid-based Anaesthesia (NA)
- Venous Cannulation Pain to Guide Choice of Anesthetic Method (NA)
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- ESKETamine for FIBromyalgia Treatment (NA)
- Virtual Reality MObility for Burn Patients (NA)
- Treatment Resistant Depression (Pilot) (NA)
- Propofol With Clonidine and Ketamine Throughout Colon Cancer Surgery (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ketamine + clonidine CI brief — competitive landscape report
- ketamine + clonidine updates RSS · CI watch RSS
- Irmandade da Santa Casa de Misericordia de Sao Paulo portfolio CI