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Joint injection with triamcinolone hexacetonide
Triamcinolone hexacetonide is a long-acting corticosteroid that suppresses local inflammation and immune responses when injected directly into a joint.
Triamcinolone hexacetonide is a long-acting corticosteroid that suppresses local inflammation and immune responses when injected directly into a joint. Used for Intra-articular inflammation in rheumatoid arthritis, Osteoarthritis joint pain and inflammation, Other inflammatory joint conditions.
At a glance
| Generic name | Joint injection with triamcinolone hexacetonide |
|---|---|
| Sponsor | Federal University of São Paulo |
| Drug class | Corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Rheumatology/Orthopedics |
| Phase | FDA-approved |
Mechanism of action
Triamcinolone hexacetonide binds to glucocorticoid receptors in synovial tissue, reducing the production of pro-inflammatory cytokines and inhibiting immune cell infiltration. The hexacetonide ester formulation provides sustained local release, allowing for prolonged anti-inflammatory effects with minimal systemic absorption when administered as an intra-articular injection.
Approved indications
- Intra-articular inflammation in rheumatoid arthritis
- Osteoarthritis joint pain and inflammation
- Other inflammatory joint conditions
Common side effects
- Local joint pain or swelling post-injection
- Transient increase in joint symptoms
- Infection at injection site
- Systemic corticosteroid effects (with repeated injections)
Key clinical trials
- Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone (PHASE4)
- Knee Injections for Obese Patients With Knee Arthritis (PHASE4)
- A Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft (ActiveMatrix) Verses Standard of Care in Adhesive Capsulitis of the Shoulder (PHASE4)
- Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain: A Prospective, Randomized Pilot Study (NA)
- Intraarticular Steroids, Saline and Occupational Therapy in People With CMC1 Osteoarthritis (PHASE4)
- The Effect of Micro Fragmented Adipose Tissue (MFAT) on Knee Osteoarthritis (PHASE3)
- The Efficacy of Ultrasonication in Combination With Corticosteroid Intraarticular Injection for Arthritis (NA)
- Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Shoulder Osteoarthritis(OA) (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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