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IV Saline bolus and infusion
IV saline bolus and infusion restores intravascular fluid volume and electrolyte balance by delivering isotonic sodium chloride solution directly into the bloodstream.
IV saline bolus and infusion restores intravascular fluid volume and electrolyte balance by delivering isotonic sodium chloride solution directly into the bloodstream. Used for Hypovolemia and dehydration, Hemorrhagic and septic shock, Perioperative fluid maintenance and replacement.
At a glance
| Generic name | IV Saline bolus and infusion |
|---|---|
| Sponsor | University of Auckland, New Zealand |
| Drug class | Crystalloid fluid / Electrolyte replacement |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Emergency Medicine / Fluid Management |
| Phase | FDA-approved |
Mechanism of action
Intravenous saline (0.9% sodium chloride) is an isotonic crystalloid fluid that expands the intravascular compartment without causing osmotic fluid shifts. It replaces lost circulating volume in dehydration, hemorrhage, or shock states, and maintains serum sodium and chloride concentrations. The bolus form delivers rapid volume expansion for acute hemodynamic support, while continuous infusion maintains hydration and electrolyte homeostasis.
Approved indications
- Hypovolemia and dehydration
- Hemorrhagic and septic shock
- Perioperative fluid maintenance and replacement
- Electrolyte imbalance correction
Common side effects
- Hyperchloremic acidosis
- Fluid overload / pulmonary edema
- Hypernatremia
- Phlebitis at infusion site
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery (PHASE4)
- Safety and Efficacy of Dexmedetomidate vs. Midazolam for Procedural Sedation During Medical Thoracoscopy (PHASE3)
- A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer (PHASE3)
- Effect of IV Lidocaine on Duodenal Peristalsis and Sedation in ERCP (PHASE4)
- Safety and Efficacy of Dexmedetomidine in Controlling Hemodynamics During Resection of Active Thyroid Secreting Tumors (PHASE2, PHASE3)
- Lymphodepletion Plus Adoptive Cell Therapy With High Dose IL-2 in Adolescent and Young Adult Patients With Soft Tissue Sarcoma (PHASE1)
- Optimizing Pain Treatment in Children On Mechanical Ventilation (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- IV Saline bolus and infusion CI brief — competitive landscape report
- IV Saline bolus and infusion updates RSS · CI watch RSS
- University of Auckland, New Zealand portfolio CI