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IV lignocaine bolus and infusion
Lignocaine (lidocaine) is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Lignocaine (lidocaine) is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Acute ventricular arrhythmias (particularly ventricular ectopy and ventricular tachycardia), Local anesthesia (infiltration, regional, topical).
At a glance
| Generic name | IV lignocaine bolus and infusion |
|---|---|
| Also known as | Lidocaine |
| Sponsor | University of Auckland, New Zealand |
| Drug class | Local anesthetic; Class IB antiarrhythmic agent |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular; Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lignocaine reversibly binds to voltage-gated sodium channels on the inner surface of nerve cell membranes, inhibiting sodium influx and preventing depolarization. This suppresses the generation and propagation of action potentials in sensory and motor nerves. When administered intravenously as a bolus and infusion, it has systemic effects including antiarrhythmic properties, particularly useful in acute ventricular arrhythmias.
Approved indications
- Acute ventricular arrhythmias (particularly ventricular ectopy and ventricular tachycardia)
- Local anesthesia (infiltration, regional, topical)
Common side effects
- Dizziness or lightheadedness
- Tremor or twitching
- Nausea
- Hypotension
- Bradycardia
- Seizures (at high doses)
- Cardiac arrhythmias (paradoxical)
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery (PHASE4)
- Systemic and Local Levels of Lidocaine During Surgery for the Removal of Glioblastoma (PHASE1)
- Effect of IV Lidocaine on Duodenal Peristalsis and Sedation in ERCP (PHASE4)
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- IV Lidocaine Infusion Versus Placebo for Pain Control in Staging Laparoscopy Cases (NA)
- Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery (PHASE3)
- Spinal Morphine or Intravenous Lidocaine in Robot-assisted Upper Urologic Surgery (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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