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IV Lidocaine
IV lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
IV lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia and infiltration anesthesia, Ventricular arrhythmias (acute management), Postoperative pain management.
At a glance
| Generic name | IV Lidocaine |
|---|---|
| Also known as | lidocaine infusion |
| Sponsor | University of Washington |
| Drug class | Local anesthetic / Antiarrhythmic agent (Class IB) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Cardiology |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels, thereby stabilizing the neuronal membrane and raising the threshold for electrical excitability. This action prevents depolarization and propagation of action potentials in sensory and motor nerves. When administered intravenously, it also has systemic antiarrhythmic properties by suppressing ectopic cardiac activity.
Approved indications
- Local anesthesia and infiltration anesthesia
- Ventricular arrhythmias (acute management)
- Postoperative pain management
Common side effects
- Dizziness or lightheadedness
- Drowsiness or sedation
- Tremor or twitching
- Hypotension
- Bradycardia
- Cardiac arrhythmias (at high doses)
- Allergic reactions (rare)
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- Sphenopalatine Ganglion Block for Post-Dural Puncture Headache: A Pilot Randomised Controlled Trial (NA)
- Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy (PHASE4)
- The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery (PHASE4)
- Study Comparing Local/ MAC Anesthesia in Lumbar Decompression (EARLY_PHASE1)
- Using Lidocaine or Dexmedetomidine to Help Control Blood Pressure Spikes From a Tourniquet During Knee Surgery (PHASE2)
- Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass (NA)
- Lidocaine IV Injection With Different Doses for Patients With Neuropathic Pain After Mastectomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- IV Lidocaine CI brief — competitive landscape report
- IV Lidocaine updates RSS · CI watch RSS
- University of Washington portfolio CI