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IV Iron (standard of care)
IV Iron (standard of care) is a Iron replacement therapy Small molecule drug developed by Nicoletta C Machin. It is currently in Phase 3 development for Iron deficiency anemia in patients intolerant of or unresponsive to oral iron, Iron deficiency anemia in chronic kidney disease patients on hemodialysis, Perioperative iron replacement.
IV iron replenishes depleted iron stores by delivering iron directly into the bloodstream for incorporation into hemoglobin and other iron-dependent proteins.
IV iron replenishes depleted iron stores by delivering iron directly into the bloodstream for incorporation into hemoglobin and other iron-dependent proteins. Used for Iron deficiency anemia in patients intolerant of or unresponsive to oral iron, Iron deficiency anemia in chronic kidney disease patients on hemodialysis, Perioperative iron replacement.
At a glance
| Generic name | IV Iron (standard of care) |
|---|---|
| Sponsor | Nicoletta C Machin |
| Drug class | Iron replacement therapy |
| Modality | Small molecule |
| Therapeutic area | Hematology |
| Phase | Phase 3 |
Mechanism of action
Intravenous iron formulations bypass gastrointestinal absorption limitations and rapidly restore systemic iron levels in patients with iron deficiency anemia. The iron is transported to bone marrow erythroid precursors and other tissues where it is incorporated into hemoglobin, myoglobin, and iron-dependent enzymes, restoring oxygen-carrying capacity and metabolic function.
Approved indications
- Iron deficiency anemia in patients intolerant of or unresponsive to oral iron
- Iron deficiency anemia in chronic kidney disease patients on hemodialysis
- Perioperative iron replacement
Common side effects
- Injection site reactions (pain, discoloration)
- Headache
- Nausea
- Hypersensitivity reactions
- Dizziness
Key clinical trials
- Effect of Intravenous Iron on Quality of Life in Older Patients With Acute Coronary Syndrome (PHASE4)
- Advanced Imaging Techniques for Evaluating the Tumor Immune Microenvironment in Glioblastoma Patients (PHASE3)
- Post-operative Intravenous Iron to Treat Iron-deficiency Anemia in Patients Undergoing Cardiac Surgery (PHASE2)
- Darbe Plus IV Iron to Decrease Transfusions While Maintaining Iron Sufficiency in Preterm Infants (PHASE2)
- Controlled Trial of Omadacycline Randomized Treatment Given for Bone and Joint Infection (PHASE2)
- Sucrosomial Vs Intravenous Iron for Preoperative Anemia (PHASE4)
- Restoring Iron Deficiency in POTS (PHASE2)
- A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- IV Iron (standard of care) CI brief — competitive landscape report
- IV Iron (standard of care) updates RSS · CI watch RSS
- Nicoletta C Machin portfolio CI
Frequently asked questions about IV Iron (standard of care)
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Related
- Drug class: All Iron replacement therapy drugs
- Manufacturer: Nicoletta C Machin — full pipeline
- Therapeutic area: All drugs in Hematology
- Indication: Drugs for Iron deficiency anemia in patients intolerant of or unresponsive to oral iron
- Indication: Drugs for Iron deficiency anemia in chronic kidney disease patients on hemodialysis
- Indication: Drugs for Perioperative iron replacement
- Compare: IV Iron (standard of care) vs similar drugs
- Pricing: IV Iron (standard of care) cost, discount & access