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IV Aminophylline
Aminophylline is a xanthine derivative that inhibits phosphodiesterase enzymes and blocks adenosine receptors, leading to increased intracellular cAMP and bronchodilation.
Aminophylline is a xanthine derivative that inhibits phosphodiesterase enzymes and blocks adenosine receptors, leading to increased intracellular cAMP and bronchodilation. Used for Acute asthma exacerbation, Chronic obstructive pulmonary disease (COPD), Apnea of prematurity.
At a glance
| Generic name | IV Aminophylline |
|---|---|
| Also known as | Minophylline-N ampoule |
| Sponsor | Damanhour Teaching Hospital |
| Drug class | Xanthine bronchodilator |
| Target | Phosphodiesterase; adenosine receptors |
| Modality | Small molecule |
| Therapeutic area | Respiratory |
| Phase | FDA-approved |
Mechanism of action
Aminophylline works primarily by inhibiting phosphodiesterase, which prevents the breakdown of cyclic adenosine monophosphate (cAMP), thereby increasing cAMP levels in smooth muscle cells and promoting relaxation. Additionally, it antagonizes adenosine receptors, which contributes to its bronchodilatory and stimulant effects. These mechanisms make it effective as a bronchodilator and respiratory stimulant, particularly useful in acute asthma exacerbations and apnea of prematurity.
Approved indications
- Acute asthma exacerbation
- Chronic obstructive pulmonary disease (COPD)
- Apnea of prematurity
- Respiratory depression
Common side effects
- Tachycardia
- Nausea and vomiting
- Headache
- Tremor
- Arrhythmias
- Insomnia
Key clinical trials
- A Study to Evaluate Efficacy, Safety, and Tolerability of Alemtuzumab in Pediatric Patients With RRMS With Disease Activity on Prior DMT (PHASE3)
- Prevention of Cisplatin-induced Nephrotoxicity (PHASE2, PHASE3)
- Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage (PHASE1, PHASE2)
- Reversal of Complete Heart Block With Aminophylline in Inferior Wall Myocardial Infarction Patients (PHASE4)
- Comparison of the Effect of Aminophylline, Magnesium Sulphate and Placebo in Prevention of Post Dural Puncture Headache in Parturient Undergoing Caesarean Section.
- Aminophylline on Perioperative Lung Mechanics in COPD Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery (NA)
- Diuretic Efficacy of Aminophylline and Furosemide Combination vs Furosemide Alone in Critically Ill Adults (PHASE2, PHASE3)
- Attenuation of the Side Effect Profile of Regadenoson: Study With Aminophylline in Patients With Severe Kidney Disease Undergoing Myocardial Perfusion Imaging (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- IV Aminophylline CI brief — competitive landscape report
- IV Aminophylline updates RSS · CI watch RSS
- Damanhour Teaching Hospital portfolio CI