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IV acetaminophen & IV propofol
This is a combination of two separate drugs: acetaminophen (a non-opioid analgesic and antipyretic) and propofol (an intravenous sedative-hypnotic agent).
This is a combination of two separate drugs: acetaminophen (a non-opioid analgesic and antipyretic) and propofol (an intravenous sedative-hypnotic agent). Used for Perioperative pain management and sedation, Critical care sedation with analgesic component.
At a glance
| Generic name | IV acetaminophen & IV propofol |
|---|---|
| Also known as | Ofirmev, Diprivan |
| Sponsor | Beth Israel Deaconess Medical Center |
| Drug class | Analgesic/antipyretic and sedative-hypnotic combination |
| Modality | Small molecule |
| Therapeutic area | Anesthesia, Critical Care, Pain Management |
| Phase | FDA-approved |
Mechanism of action
Acetaminophen works by inhibiting prostaglandin synthesis in the central nervous system to reduce pain and fever. Propofol is a rapid-acting sedative that enhances GABAergic inhibitory neurotransmission in the central nervous system, producing sedation and anesthesia. When used together intravenously, they provide combined analgesia, antipyresis, and sedation for perioperative and critical care settings.
Approved indications
- Perioperative pain management and sedation
- Critical care sedation with analgesic component
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain (propofol)
- Hepatotoxicity (acetaminophen at high doses)
Key clinical trials
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- Transition From Acute to Chronic Opioid Use and Chronic Pain (EARLY_PHASE1)
- Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies (NA)
- Anesthetic Optimization in Pediatric LeFort Surgeries (NA)
- Effect of Ketorolac on Post Adenotonsillectomy Pain (PHASE4)
- Opioid-free Anesthesia as an Alternative to General Anesthesia in Abdominal Surgery (NA)
- A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery (NA)
- Opioid Based Analgesia vs Non-opioid Analgesia for Oocyte Retrieval Procedure (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- IV acetaminophen & IV propofol CI brief — competitive landscape report
- IV acetaminophen & IV propofol updates RSS · CI watch RSS
- Beth Israel Deaconess Medical Center portfolio CI