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Isotonic solution (NaCl 0.9%)
Isotonic saline (0.9% NaCl) maintains osmotic balance and replaces fluid losses without altering electrolyte concentrations.
Isotonic saline (0.9% NaCl) maintains osmotic balance and replaces fluid losses without altering electrolyte concentrations. Used for Fluid replacement and maintenance in dehydration, Vehicle for intravenous drug administration, Perioperative fluid management.
At a glance
| Generic name | Isotonic solution (NaCl 0.9%) |
|---|---|
| Sponsor | IRCCS Burlo Garofolo |
| Drug class | Crystalloid fluid / Electrolyte solution |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Fluid Management |
| Phase | Phase 3 |
Mechanism of action
This solution contains sodium chloride at a concentration (0.9%) that is isotonic with human blood plasma, meaning it has the same osmotic pressure and does not cause water to move into or out of cells. It is used primarily for fluid replacement, maintaining hydration, and as a vehicle for intravenous drug administration. It is a physiologic solution that restores intravascular volume without causing electrolyte imbalances.
Approved indications
- Fluid replacement and maintenance in dehydration
- Vehicle for intravenous drug administration
- Perioperative fluid management
Common side effects
- Hyperchloremic acidosis (with large volumes)
- Fluid overload / Pulmonary edema (in susceptible patients)
- Hypokalemia (with prolonged use without electrolyte supplementation)
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- Magnesium Supplementation in Advanced Non-small Cell Lung Cancer (NSCLC) (PHASE2, PHASE3)
- Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1) (PHASE1)
- Repeated Bilateral Greater Occipital Nerve Blockade in Chronic Migraine and Chronic Tension-Type Headache (NA)
- Normal Saline Infusion After Intravenous Thrombolysis in Stroke (PHASE3)
- Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fasciocutaneous Flap-Based Closure of Pilonidal Disease (NA)
- Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome (PHASE4)
- Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |