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Isotonic crystalloids
Isotonic crystalloids is a Intravenous fluid / Crystalloid solution Small molecule drug developed by Marie Kristine Jessen, MD. It is currently FDA-approved for Hypovolemic shock and acute blood loss resuscitation, Perioperative fluid maintenance and replacement, Dehydration and electrolyte imbalance correction.
Isotonic crystalloids restore intravascular volume and maintain electrolyte balance by providing a physiologically balanced solution of water and electrolytes that distributes across body fluid compartments.
Isotonic crystalloids, also known as 0.9% saline solution, are a type of small molecule modality used in medical treatments. They have been studied in various clinical trials, including those for anesthesia, cancer, and bradycardia, and have been used as interventions in studies such as the comparison of atropine or ephedrine pretreatment for preventing bradycardia in elderly patients.
At a glance
| Generic name | Isotonic crystalloids |
|---|---|
| Sponsor | Marie Kristine Jessen, MD |
| Drug class | Intravenous fluid / Crystalloid solution |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Emergency Medicine / Perioperative Medicine |
| Phase | FDA-approved |
Mechanism of action
Isotonic crystalloids (such as normal saline 0.9% and lactated Ringer's solution) are intravenous fluids with osmolarity matching plasma, allowing them to equilibrate across the intracellular and extracellular compartments without causing cellular water shifts. They restore circulating volume in hypovolemic states, maintain electrolyte homeostasis, and serve as the first-line fluid resuscitation agent in acute care settings. These solutions do not contain colloids or medications and work purely through volume expansion and osmotic balance.
Approved indications
- Hypovolemic shock and acute blood loss resuscitation
- Perioperative fluid maintenance and replacement
- Dehydration and electrolyte imbalance correction
- Burn injury fluid resuscitation
Common side effects
- Hyperchloremic acidosis
- Fluid overload / pulmonary edema
- Hypokalemia
- Phlebitis at infusion site
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1) (PHASE1)
- Repeated Bilateral Greater Occipital Nerve Blockade in Chronic Migraine and Chronic Tension-Type Headache (NA)
- Normal Saline Infusion After Intravenous Thrombolysis in Stroke (PHASE3)
- Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fasciocutaneous Flap-Based Closure of Pilonidal Disease (NA)
- Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome (PHASE4)
- Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial (PHASE3)
- The Development of New Functions of Esculin and Digitalis Glycosides Eye Drops: A Study on the Treatment of Presbyopia (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Isotonic crystalloids CI brief — competitive landscape report
- Isotonic crystalloids updates RSS · CI watch RSS
- Marie Kristine Jessen, MD portfolio CI
Frequently asked questions about Isotonic crystalloids
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Related
- Drug class: All Intravenous fluid / Crystalloid solution drugs
- Manufacturer: Marie Kristine Jessen, MD — full pipeline
- Therapeutic area: All drugs in Critical Care / Emergency Medicine / Perioperative Medicine
- Indication: Drugs for Hypovolemic shock and acute blood loss resuscitation
- Indication: Drugs for Perioperative fluid maintenance and replacement
- Indication: Drugs for Dehydration and electrolyte imbalance correction
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing