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Isoflurane Volatile Liquid
Isoflurane is a volatile anesthetic that enhances inhibitory neurotransmission and suppresses excitatory signaling in the central nervous system to produce anesthesia.
Isoflurane is a volatile anesthetic that enhances inhibitory neurotransmission and suppresses excitatory signaling in the central nervous system to produce anesthesia. Used for General anesthesia for surgical procedures, Maintenance of anesthesia during surgery.
At a glance
| Generic name | Isoflurane Volatile Liquid |
|---|---|
| Also known as | isoflurane |
| Sponsor | Federal University of São Paulo |
| Drug class | Volatile anesthetic |
| Target | GABA-A receptor, NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Isoflurane potentiates GABA-A receptor activity and inhibits NMDA glutamate receptors, leading to depression of neuronal activity and loss of consciousness. It also modulates other ion channels and neurotransmitter systems. The drug is administered by inhalation and rapidly crosses the blood-brain barrier to produce dose-dependent anesthetic effects.
Approved indications
- General anesthesia for surgical procedures
- Maintenance of anesthesia during surgery
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Postoperative nausea and vomiting
- Emergence delirium
- Hepatotoxicity (rare)
Key clinical trials
- Effect & Safety of Inhaled Isoflurane vs IV Midazolam for Sedation in Mechanically Ventilated Children 3-17 Years Old (PHASE3)
- Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Isoflurane Volatile Liquid CI brief — competitive landscape report
- Isoflurane Volatile Liquid updates RSS · CI watch RSS
- Federal University of São Paulo portfolio CI