Last reviewed · How we verify
Isobaric bupivacaine 0.5%
Isobaric bupivacaine blocks sodium channels in nerve fibers to produce local anesthesia with a specific gravity matching cerebrospinal fluid.
Isobaric bupivacaine blocks sodium channels in nerve fibers to produce local anesthesia with a specific gravity equal to cerebrospinal fluid, allowing it to remain at the injection site without migration. Used for Local and regional anesthesia for surgical procedures, Spinal anesthesia.
At a glance
| Generic name | Isobaric bupivacaine 0.5% |
|---|---|
| Also known as | B solution |
| Sponsor | Hospital Clínico Universitario de Valencia |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that inhibits sodium influx through voltage-gated sodium channels in nerve cell membranes, preventing depolarization and action potential propagation. The isobaric formulation has a specific gravity equal to cerebrospinal fluid, allowing it to remain at the injection site without significant migration during spinal anesthesia, providing more predictable and localized anesthetic effects.
Approved indications
- Local and regional anesthesia for surgical procedures
- Spinal anesthesia
Common side effects
- Hypotension
- Bradycardia
- Headache
- Neurological toxicity (at high doses)
- Cardiovascular toxicity (at high doses)
Key clinical trials
- The Effect of Epidural Anesthesia on Optic Nerve Sheath Diameter Measurements in Total Knee Prosthesis Surgery (NA)
- Comparison of Lumbar Erector Spinae Plane Block and Spinal Anesthesia in Hip and Proximal Femur Surgery (NA)
- Maxillary and Mandibular Nerve Block (NA)
- Caudal Dexmedetomidine vs Ketamine for Postoperative Analgesia in Pediatric DDH Surgery (NA)
- Sensory Block Onset: Epidural vs Dural Puncture Epidural in Cesarean Section (NA)
- Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy. (NA)
- Prevention of Rebound Pain After Axillary Block (NA)
- Post-Operative Urinary Retention on Revision Knee Arthroplasty: the Role of Intrathecal Morphine (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Isobaric bupivacaine 0.5% CI brief — competitive landscape report
- Isobaric bupivacaine 0.5% updates RSS · CI watch RSS
- Hospital Clínico Universitario de Valencia portfolio CI