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IPTp-sulphadoxine-pyrimethamine plus metronidazole
IPTp-sulphadoxine-pyrimethamine plus metronidazole is a Antifolate antimalarial + nitroimidazole antibiotic Small molecule drug developed by London School of Hygiene and Tropical Medicine. It is currently in Phase 3 development for Malaria prevention in pregnant women (intermittent preventive treatment), Reduction of adverse pregnancy outcomes associated with malaria infection. Also known as: Fansidar, Flagyl.
This combination therapy prevents malaria and treats bacterial/parasitic infections in pregnant women through antifolate antimalarial activity and broad-spectrum antimicrobial action.
This combination therapy prevents malaria and treats bacterial/parasitic infections in pregnant women through antifolate antimalarial activity and broad-spectrum antimicrobial action. Used for Malaria prevention in pregnant women (intermittent preventive treatment), Reduction of adverse pregnancy outcomes associated with malaria infection.
At a glance
| Generic name | IPTp-sulphadoxine-pyrimethamine plus metronidazole |
|---|---|
| Also known as | Fansidar, Flagyl |
| Sponsor | London School of Hygiene and Tropical Medicine |
| Drug class | Antifolate antimalarial + nitroimidazole antibiotic |
| Target | Plasmodial dihydrofolate reductase (SP); bacterial/parasitic DNA (metronidazole) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Obstetrics |
| Phase | Phase 3 |
Mechanism of action
Sulphadoxine-pyrimethamine (SP) is an antifolate combination that inhibits plasmodial dihydrofolate reductase, preventing malaria parasites from synthesizing nucleotides. Metronidazole is a nitroimidazole that disrupts bacterial and parasitic DNA, providing additional coverage against anaerobic bacteria and protozoa. IPTp (intermittent preventive treatment in pregnancy) uses this combination to reduce malaria infection and associated adverse pregnancy outcomes.
Approved indications
- Malaria prevention in pregnant women (intermittent preventive treatment)
- Reduction of adverse pregnancy outcomes associated with malaria infection
Common side effects
- Gastrointestinal disturbance
- Metallic taste (metronidazole)
- Allergic reactions (sulphonamide sensitivity)
- Peripheral neuropathy (rare)
Key clinical trials
- The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive Tract (PHASE3)
- Nutritional and Anti-infective Interventions for Malnutrition in Pregnancy (Beleuman Welbodi) (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- IPTp-sulphadoxine-pyrimethamine plus metronidazole CI brief — competitive landscape report
- IPTp-sulphadoxine-pyrimethamine plus metronidazole updates RSS · CI watch RSS
- London School of Hygiene and Tropical Medicine portfolio CI
Frequently asked questions about IPTp-sulphadoxine-pyrimethamine plus metronidazole
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Related
- Drug class: All Antifolate antimalarial + nitroimidazole antibiotic drugs
- Target: All drugs targeting Plasmodial dihydrofolate reductase (SP); bacterial/parasitic DNA (metronidazole)
- Manufacturer: London School of Hygiene and Tropical Medicine — full pipeline
- Therapeutic area: All drugs in Infectious Disease / Obstetrics
- Indication: Drugs for Malaria prevention in pregnant women (intermittent preventive treatment)
- Indication: Drugs for Reduction of adverse pregnancy outcomes associated with malaria infection
- Also known as: Fansidar, Flagyl
- Compare: IPTp-sulphadoxine-pyrimethamine plus metronidazole vs similar drugs
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