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IPTp-dihydroartemisinin-piperaquine plus metronidazole
IPTp-dihydroartemisinin-piperaquine plus metronidazole is a Antimalarial combination with antibiotic/antiprotozoal agent Small molecule drug developed by London School of Hygiene and Tropical Medicine. It is currently in Phase 3 development for Intermittent preventive therapy in pregnancy (IPTp) for malaria prevention in pregnant women in malaria-endemic regions, Prevention of malaria and associated infections during pregnancy. Also known as: Flagyl, D-ARTEPP®.
This combination drug uses dihydroartemisinin-piperaquine to treat malaria parasites and metronidazole to treat bacterial and protozoal infections, administered as intermittent preventive therapy in pregnancy.
This combination drug uses dihydroartemisinin-piperaquine to treat malaria parasites and metronidazole to treat bacterial and protozoal infections, administered as intermittent preventive therapy in pregnancy. Used for Intermittent preventive therapy in pregnancy (IPTp) for malaria prevention in pregnant women in malaria-endemic regions, Prevention of malaria and associated infections during pregnancy.
At a glance
| Generic name | IPTp-dihydroartemisinin-piperaquine plus metronidazole |
|---|---|
| Also known as | Flagyl, D-ARTEPP® |
| Sponsor | London School of Hygiene and Tropical Medicine |
| Drug class | Antimalarial combination with antibiotic/antiprotozoal agent |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Dihydroartemisinin-piperaquine is an artemisinin-based combination therapy that kills malaria parasites through multiple mechanisms including generation of reactive oxygen species and inhibition of parasite protein synthesis. Metronidazole is a nitroimidazole that generates cytotoxic free radicals to eliminate anaerobic bacteria and certain protozoa. Together, this combination aims to prevent malaria and associated infections during pregnancy (IPTp = Intermittent Preventive Therapy in pregnancy).
Approved indications
- Intermittent preventive therapy in pregnancy (IPTp) for malaria prevention in pregnant women in malaria-endemic regions
- Prevention of malaria and associated infections during pregnancy
Common side effects
- Nausea
- Vomiting
- Abdominal pain
- Metallic taste (metronidazole)
- Headache
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- IPTp-dihydroartemisinin-piperaquine plus metronidazole CI brief — competitive landscape report
- IPTp-dihydroartemisinin-piperaquine plus metronidazole updates RSS · CI watch RSS
- London School of Hygiene and Tropical Medicine portfolio CI
Frequently asked questions about IPTp-dihydroartemisinin-piperaquine plus metronidazole
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Related
- Drug class: All Antimalarial combination with antibiotic/antiprotozoal agent drugs
- Manufacturer: London School of Hygiene and Tropical Medicine — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Intermittent preventive therapy in pregnancy (IPTp) for malaria prevention in pregnant women in malaria-endemic regions
- Indication: Drugs for Prevention of malaria and associated infections during pregnancy
- Also known as: Flagyl, D-ARTEPP®
- Compare: IPTp-dihydroartemisinin-piperaquine plus metronidazole vs similar drugs
- Pricing: IPTp-dihydroartemisinin-piperaquine plus metronidazole cost, discount & access