Last reviewed 2026-06-01 · How we verify

IONIS DGAT2Rx

Ionis Pharmaceuticals, Inc. · Phase 2 active Small molecule ✓ Verified Jun 2026

IONIS DGAT2Rx is a Small molecule drug developed by Ionis Pharmaceuticals, Inc.. It is currently in Phase 2 development.

IONIS DGAT2Rx is an antisense inhibitor oligonucleotide that targets the ENaC mRNA. It is being studied in a clinical trial for the treatment of Hepatic Steatosis in adult patients with Type 2 Diabetes.

Likelihood of approval

15.3% vs 15.3% industry baseline

If approved by FDA: likely 2031–2034

Steps remaining: Phase 3 → NDA/BLA submission

Confidence: Medium

Why this estimate

Baseline phase 2 → approval rate +15.3pp
Industry-wide phase 2 drugs reach approval ~15.3% of the time (BIO/Informa 2023 industry benchmark across all therapeutic areas).

Predicted approval windows by jurisdiction (conditional on FDA approval)

Regulator	Country	Likely year	Lag vs FDA
FDA	US	2031–2034	—
EMA	EU	2032–2035	+0.7 yr
MHRA	GB	2032–2035	+0.7 yr
Health Canada	CA	2032–2036	+0.9 yr
TGA	AU	2032–2036	+1.2 yr
PMDA	JP	2032–2036	+1.5 yr
NMPA	CN	2033–2037	+2.3 yr
MFDS	KR	2032–2036	+1.4 yr
CDSCO	IN	2032–2037	+1.8 yr
ANVISA	BR	2033–2037	+2.3 yr

Hover any row for the lag rationale. Lag estimates are reduced when the drug has FDA Breakthrough or EMA PRIME designation (sponsors file globally in parallel).

Estimate based on the BIO/Informa industry phase transition rates plus per-drug modifiers for therapeutic area, sponsor type, FDA designations, mechanism, and trial design. Per-jurisdiction lags from Tufts CSDD international approval studies. Not investment, clinical or regulatory advice. Methodology: /methodology#likelihood.

At a glance

Generic name	IONIS DGAT2Rx
Sponsor	Ionis Pharmaceuticals, Inc.
Modality	Small molecule
Phase	Phase 2

Approved indications

No approved indications tracked.

Common side effects

No common side effects on file.

Key clinical trials

Safety, Tolerability, and Pharmacodynamics of IONIS-DGAT2Rx in Adult Patients With Type 2 Diabetes (PHASE2)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
ClinicalTrials.gov	Trial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

IONIS DGAT2Rx CI brief — competitive landscape report
IONIS DGAT2Rx updates RSS · CI watch RSS
Ionis Pharmaceuticals, Inc. portfolio CI

Frequently asked questions about IONIS DGAT2Rx

What is IONIS DGAT2Rx?

IONIS DGAT2Rx is a Small molecule drug developed by Ionis Pharmaceuticals, Inc..

Who makes IONIS DGAT2Rx?

IONIS DGAT2Rx is developed by Ionis Pharmaceuticals, Inc. (see full Ionis Pharmaceuticals, Inc. pipeline at /company/ionis-pharmaceuticals-inc).

What development phase is IONIS DGAT2Rx in?

IONIS DGAT2Rx is in Phase 2.

Manufacturer: Ionis Pharmaceuticals, Inc. — full pipeline

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing