Last reviewed · How we verify
Intravenous sodium bicarbonate
Sodium bicarbonate acts as a buffer to neutralize excess acid in the blood and urine, raising pH to counteract acidosis.
Sodium bicarbonate acts as a buffer to neutralize excess acid in the blood and urine, raising pH to counteract acidosis. Used for Metabolic acidosis, Urinary alkalinization for drug or toxin elimination, Diabetic ketoacidosis.
At a glance
| Generic name | Intravenous sodium bicarbonate |
|---|---|
| Sponsor | The Western Pennsylvania Hospital |
| Drug class | Alkalinizing agent |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Toxicology / Metabolic Disorders |
| Phase | FDA-approved |
Mechanism of action
Sodium bicarbonate dissociates to provide bicarbonate ions that bind hydrogen ions, shifting the acid-base equilibrium toward a more alkaline state. This is used to treat metabolic acidosis, alkalinize urine to enhance renal excretion of certain drugs or toxins, and manage conditions like diabetic ketoacidosis or tricyclic antidepressant overdose.
Approved indications
- Metabolic acidosis
- Urinary alkalinization for drug or toxin elimination
- Diabetic ketoacidosis
- Tricyclic antidepressant overdose
- Severe hyperkalemia (adjunctive)
Common side effects
- Hypernatremia
- Hypokalemia
- Metabolic alkalosis
- Fluid overload
- Phlebitis at injection site
Key clinical trials
- Evaluating the Clinical Effectiveness of Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosis and Acute Kidney Injury (PHASE4)
- Role of Combination Therapy of Glucose Insulin Potassium Infusion (GIK), Intravenous Hydrocortisone and Oral Sevelamer in Treatment of Acute Aluminum Phosphide Poisoned Cases Admitted to Intensive Care Unit (ICU) at Sohag University Hospitals. (NA)
- Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment (PHASE4)
- Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's Lymphoma (PHASE2)
- Application of Sodium Bicarbonate Ringer's Solution in Laparoscopic Hepatectomy (NA)
- Lignocaine Versus Sodium Bicarbonate on Reducing Pain During Propofol Injection (EARLY_PHASE1)
- Sodium Bicarbonate for the Treatment of Severe Metabolic Acidosis With Moderate or Severe Acute Kidney Injury in ICU (NA)
- Efficacy and Safety of HAIC in Combination With TQB2868 and Ramucirumab for Second-line Treatment of Advanced Hepatocellular Carcinoma (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Intravenous sodium bicarbonate CI brief — competitive landscape report
- Intravenous sodium bicarbonate updates RSS · CI watch RSS
- The Western Pennsylvania Hospital portfolio CI