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Intraoperative analgesia
Intraoperative analgesia refers to pain management strategies and medications administered during surgical procedures to prevent and control pain in real-time.
Intraoperative analgesia refers to pain management strategies and medications administered during surgical procedures to prevent and control pain in real-time. Used for Pain management during surgical procedures.
At a glance
| Generic name | Intraoperative analgesia |
|---|---|
| Also known as | Fentanyl, Ketorolac, Tramadol |
| Sponsor | Iuliu Hatieganu University of Medicine and Pharmacy |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology / Perioperative Medicine |
| Phase | FDA-approved |
Mechanism of action
This is a therapeutic approach rather than a single drug entity, typically involving opioids, local anesthetics, regional anesthesia techniques, and/or non-opioid analgesics administered perioperatively. The goal is to block nociceptive signaling through multiple mechanisms—including mu-opioid receptor agonism, sodium channel blockade, and NMDA receptor antagonism—to maintain analgesia and reduce postoperative pain.
Approved indications
- Pain management during surgical procedures
Common side effects
- Respiratory depression
- Hypotension
- Nausea and vomiting
- Bradycardia
Key clinical trials
- Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients" (NA)
- Effects of Local Ketamine in Orthognathic Procedures (NA)
- Management of Pain in Lumbar Arthrodesis (PHASE4)
- NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty (NA)
- Virtual Reality for Postoperative Recovery After Major Abdominal Surgery (NA)
- Enhanced Recovery After Surgery (ERAS) in Patients With Peritoneal Carcinomatosis Undergoing Cytoreductive Surgery With or Without HIPEC (NA)
- Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy (PHASE4)
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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