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Saline Nasal Spray
Saline Nasal Spray is a Nasal decongestant / saline rinse Small molecule drug developed by ORA, Inc.. It is currently FDA-approved for Nasal congestion relief, Nasal irrigation and cleansing, Dry nasal passages. Also known as: Placebo, Natriumklorid b. Braun 9 mg/ml, Intranasal Placebo, Placebo Spray.
Saline nasal spray delivers a sterile salt-water solution to the nasal passages to cleanse, moisturize, and relieve nasal congestion.
Saline nasal spray is a sterile solution used in medical research as a control or placebo in studies for various conditions, including epistaxis, hereditary hemorrhagic telangiectasia, and stress disorders. The exact mechanism of action of saline nasal spray is unknown, as indicated by ChEMBL.
At a glance
| Generic name | Saline Nasal Spray |
|---|---|
| Also known as | Placebo, Natriumklorid b. Braun 9 mg/ml, Intranasal Placebo, Placebo Spray |
| Sponsor | ORA, Inc. |
| Drug class | Nasal decongestant / saline rinse |
| Modality | Small molecule |
| Therapeutic area | Otolaryngology / Respiratory |
| Phase | FDA-approved |
Mechanism of action
The isotonic or hypertonic saline solution works by osmotic action to reduce mucosal edema, flush out irritants and mucus, and restore moisture to dry nasal tissues. This mechanical cleansing and hydration helps restore normal nasal airflow and function without pharmacologically active ingredients.
Approved indications
- Nasal congestion relief
- Nasal irrigation and cleansing
- Dry nasal passages
- Post-nasal drip management
Common side effects
- Nasal irritation
- Mild stinging or burning
- Epistaxis (rare)
Key clinical trials
- Intranasal Dexmedetomidine for Prevention of Intrapartum Fever (NA)
- Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain (PHASE2)
- Intranasal Dexmedetomidine for Postpartum Depression Prevention (NA)
- Efficacy of Flurbiprofen Spray for Postoperative Sore Throat Following Double-Lumen Endobronchial Intubation (NA)
- Cromoglicate Adjunctive Therapy for Outpatients With Schizophrenia (PHASE1,PHASE2)
- Benzydamine for Radiation-Induced Oral Mucositis in Patients Receiving High-Dose Radiotherapy (PHASE4)
- The Importance of Insulin Action in the Brain for the Immune System During Physical Activity-Overweight (NA)
- Oxytocin to Treat PTSD (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Saline Nasal Spray CI brief — competitive landscape report
- Saline Nasal Spray updates RSS · CI watch RSS
- ORA, Inc. portfolio CI
Frequently asked questions about Saline Nasal Spray
What is Saline Nasal Spray?
How does Saline Nasal Spray work?
What is Saline Nasal Spray used for?
Who makes Saline Nasal Spray?
Is Saline Nasal Spray also known as anything else?
What drug class is Saline Nasal Spray in?
What development phase is Saline Nasal Spray in?
What are the side effects of Saline Nasal Spray?
Related
- Drug class: All Nasal decongestant / saline rinse drugs
- Manufacturer: ORA, Inc. — full pipeline
- Therapeutic area: All drugs in Otolaryngology / Respiratory
- Indication: Drugs for Nasal congestion relief
- Indication: Drugs for Nasal irrigation and cleansing
- Indication: Drugs for Dry nasal passages
- Also known as: Placebo, Natriumklorid b. Braun 9 mg/ml, Intranasal Placebo, Placebo Spray
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing