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Intranasal Ibuprofen
Intranasal ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) delivered directly to nasal mucosa to reduce inflammation and provide rapid pain relief.
Intranasal ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) delivered directly to nasal mucosa to reduce inflammation and provide rapid pain relief. Used for Acute pain management, Migraine headache.
At a glance
| Generic name | Intranasal Ibuprofen |
|---|---|
| Sponsor | Bezmialem Vakif University |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | COX-1, COX-2 |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Ibuprofen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis and thereby decreasing inflammation, pain, and fever. The intranasal formulation allows for rapid absorption through the nasal mucosa, potentially providing faster onset of action compared to oral administration while potentially reducing systemic exposure.
Approved indications
- Acute pain management
- Migraine headache
Common side effects
- Nasal irritation
- Headache
- Rhinitis
- Gastrointestinal upset
Key clinical trials
- Analgesic Effects of Intranasal Diclofenac Sodium, Ibuprofen, and Paracetamol in Pediatric Tonsillectomy Cases (PHASE3)
- A RCT of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture (PHASE4)
- Sprix for Postoperative Pain Control Following Gynecologic Surgery (PHASE4)
- IN Sub-Dissociative Ketamine vs IN Fentanyl (PHASE2)
- RCT Evaluating Intranasal Fentanyl in the Pain Management of Children With Headaches (PHASE4)
- Sub-dissociative Intranasal Ketamine for Pediatric Sickle Cell Pain Crises (NA)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |