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Intranasal Budesonide Spray
Budesonide is a corticosteroid that reduces inflammation in the nasal airways by suppressing immune cell activation and inflammatory mediator release.
Budesonide is a corticosteroid that reduces inflammation in the nasal airways by suppressing immune cell activation and inflammatory mediator release. Used for Allergic rhinitis, Nasal inflammation and congestion.
At a glance
| Generic name | Intranasal Budesonide Spray |
|---|---|
| Sponsor | Second Xiangya Hospital of Central South University |
| Drug class | Intranasal corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Immunology / Allergy / Respiratory |
| Phase | Phase 3 |
Mechanism of action
Budesonide binds to glucocorticoid receptors in nasal tissue, leading to decreased production of inflammatory cytokines, reduced recruitment of immune cells, and stabilization of mast cells. This results in reduced nasal inflammation, congestion, and allergic symptoms. The intranasal formulation delivers the drug directly to the site of inflammation while minimizing systemic exposure.
Approved indications
- Allergic rhinitis
- Nasal inflammation and congestion
Common side effects
- Nasal irritation
- Epistaxis (nosebleed)
- Headache
- Pharyngeal irritation
Key clinical trials
- Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Acute Sinusitis (PHASE4)
- Nebulized Nasal Steroids (PHASE1, PHASE2)
- Dupilumab in Chinese Adult Participants With CRSwNP (PHASE3)
- Nasal Obstruction With Oxymetazoline and Corticosteroids (PHASE2)
- Budesonide Irrigation in Allergic Rhinitis (PHASE4)
- Comparison of Nebulized Budesonide and Intranasal Budesonide Spray in Children With Adenotonsillar Hypertrophy (PHASE3)
- A Study of Intranasal Budesonide Aqueous Spray for Treatment of Rhinitis During Periods of High Airborne Pollution (PHASE4)
- The Efficacy of MEDIHONEY® for Chronic Rhinosinusitis With Nasal Polyposis After Functional Endoscopic Sinus Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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