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Intralesional Triamcinolone
Triamcinolone is a corticosteroid that suppresses local inflammation and immune responses when injected directly into a lesion.
Triamcinolone is a corticosteroid that suppresses local inflammation and immune responses when injected directly into a lesion. Used for Intralesional injection for inflammatory skin conditions (e.g., keloids, hypertrophic scars, lichen planus, alopecia areata).
At a glance
| Generic name | Intralesional Triamcinolone |
|---|---|
| Also known as | Kenalog |
| Sponsor | Centro Dermatológico Dr. Ladislao de la Pascua |
| Drug class | Corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Intralesional triamcinolone works by binding to glucocorticoid receptors in inflammatory cells, reducing the production of pro-inflammatory cytokines and mediators. This localized anti-inflammatory effect reduces swelling, erythema, and pruritus at the injection site while minimizing systemic exposure. The drug is commonly used for dermatologic conditions where direct tissue infiltration provides therapeutic benefit with reduced systemic side effects.
Approved indications
- Intralesional injection for inflammatory skin conditions (e.g., keloids, hypertrophic scars, lichen planus, alopecia areata)
Common side effects
- Local skin atrophy
- Hypopigmentation or hyperpigmentation
- Telangiectasia
- Local pain or burning at injection site
Key clinical trials
- Local Methotrexate Injections for the Treatment of Nail Psoriasis (PHASE4)
- Use of Steroid Injections to Prevent the Recurrence of Tracheal Stenosis in Idiopathic Subglottic Stenosis (PHASE3)
- Comparison of Topical Calcipotriol and Intralesional Steroids in Alopecia Areata (PHASE4)
- Topical Cryotherapy and Keloid/Hypertrophic Scars (PHASE3)
- Comparison of Intralesional Triamcinolone Acetonide Treatment With Intralesional Verapamil Hydrochloride in Keloids (NA)
- Intralesional Steroid Injection Versus Voice Therapy in Management of Vocal Nodules (PHASE4)
- Safety and Efficacy of Intralesional 0.5% Triamcinolone Acetonide in 0.2% Fluconazole Solution vs 0.1% Topical Mometasone Furoate With 2% Miconazole Nitrate Cream in the Treatment of Chronic Paronychia: An Intraindividual Randomized Controlled Trial. (PHASE3)
- Alternating Triamcinolone and Platelet-Rich Plasma Therapy for Oral Submucous Fibrosis (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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