Last reviewed · How we verify
Intralesional injection of bevacizumab
Intralesional injection of bevacizumab is a Monoclonal antibody (VEGF inhibitor) Small molecule drug developed by Khon Kaen University. It is currently in Phase 3 development for Intralesional treatment of solid tumors or lesions (investigational phase 3). Also known as: Avastin.
Bevacizumab is a monoclonal antibody that blocks vascular endothelial growth factor (VEGF), inhibiting new blood vessel formation to reduce tumor vascularity and nutrient supply.
Bevacizumab is a monoclonal antibody that blocks vascular endothelial growth factor (VEGF), inhibiting new blood vessel formation to reduce tumor vascularity and nutrient supply. Used for Intralesional treatment of solid tumors or lesions (investigational phase 3).
At a glance
| Generic name | Intralesional injection of bevacizumab |
|---|---|
| Also known as | Avastin |
| Sponsor | Khon Kaen University |
| Drug class | Monoclonal antibody (VEGF inhibitor) |
| Target | VEGF (Vascular Endothelial Growth Factor) |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
When injected directly into a lesion, bevacizumab binds to VEGF and prevents its interaction with VEGF receptors on endothelial cells. This inhibits angiogenesis—the formation of new blood vessels that tumors depend on for growth and metastasis. The intralesional route delivers high local concentrations directly to the target tissue while minimizing systemic exposure.
Approved indications
- Intralesional treatment of solid tumors or lesions (investigational phase 3)
Common side effects
- Local injection site reactions
- Bleeding or hemorrhage
- Wound healing complications
- Systemic VEGF inhibition effects (if significant absorption)
Key clinical trials
- Bevacizumab Versus Triamcinolone Acetonide for the Treatment of Keloids. (PHASE4)
- Preoperative Bevacizumab Injection in Primary Pterygium in Tunisian Patients (PHASE4)
- Bevacizumab Injection for Recurrent Pterygium
- Therapeutic Study of Bevacizumab Injection Directly Inside the Keloid Tissue (PHASE2)
- Bevacizumab Versus Cidofovir for the Treatment of Recurrent Respiratory Papillomatosis (PHASE2)
- Intralesional Bevacizumab for Treating AIDS-associated Kaposi´s Sarcoma of the Larynx, Pharynx and Oral Cavity (PHASE2)
- Intralesional Bevacizumab Injection on Primary Pterygium (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Intralesional injection of bevacizumab CI brief — competitive landscape report
- Intralesional injection of bevacizumab updates RSS · CI watch RSS
- Khon Kaen University portfolio CI
Frequently asked questions about Intralesional injection of bevacizumab
What is Intralesional injection of bevacizumab?
How does Intralesional injection of bevacizumab work?
What is Intralesional injection of bevacizumab used for?
Who makes Intralesional injection of bevacizumab?
Is Intralesional injection of bevacizumab also known as anything else?
What drug class is Intralesional injection of bevacizumab in?
What development phase is Intralesional injection of bevacizumab in?
What are the side effects of Intralesional injection of bevacizumab?
What does Intralesional injection of bevacizumab target?
Related
- Drug class: All Monoclonal antibody (VEGF inhibitor) drugs
- Target: All drugs targeting VEGF (Vascular Endothelial Growth Factor)
- Manufacturer: Khon Kaen University — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Intralesional treatment of solid tumors or lesions (investigational phase 3)
- Also known as: Avastin
- Compare: Intralesional injection of bevacizumab vs similar drugs
- Pricing: Intralesional injection of bevacizumab cost, discount & access