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Intra-articular injection with lidocaine
Lidocaine blocks sodium channels in nerve fibers to provide local anesthetic and analgesic effects when injected directly into the joint space.
Lidocaine blocks sodium channels in nerve fibers to provide local anesthetic and analgesic effects when injected directly into the joint space. Used for Intra-articular pain management and local anesthesia for joint procedures.
At a glance
| Generic name | Intra-articular injection with lidocaine |
|---|---|
| Also known as | Xylestesin |
| Sponsor | Federal University of São Paulo |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Rheumatology / Orthopedics |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in nerve cell membranes, thereby preventing depolarization and blocking pain signal transmission. When administered as an intra-articular injection, it provides rapid onset anesthesia and pain relief directly at the site of joint pathology, reducing pain during and after joint procedures or for chronic joint pain management.
Approved indications
- Intra-articular pain management and local anesthesia for joint procedures
Common side effects
- Local injection site reactions (pain, swelling)
- Systemic toxicity (rare, with overdose)
- Allergic reactions
Key clinical trials
- OMT for Adhesive Capsulitis (PHASE4)
- Efficacy of Autologous Conditioned Serum in Temporomandibular Joint Disorder (NA)
- Combination of Fluoroscopy and Ultrasonography Guidance in Sacroiliac Joint Injections. A Randomised Controlled Trial (NA)
- Knee Injections for Obese Patients With Knee Arthritis (PHASE4)
- A Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft (ActiveMatrix) Verses Standard of Care in Adhesive Capsulitis of the Shoulder (PHASE4)
- Low-Cost Platelet-Rich Plasma for Hemarthropathy (NA)
- Pericapsular Nerve Group Block Added to Intra-articular Corticosteroid Injection in the Treatment of Hip Pain
- Effectiveness Of Alcohol Addition In Ultrasound-Guided Periarticular Sacroiliac Joint Injection (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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