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Interruption of oral anticoagulants
Interruption of oral anticoagulants is a Small molecule drug developed by St. Antonius Hospital. It is currently FDA-approved for Perioperative management of patients on chronic oral anticoagulation, Bridging strategy for patients requiring temporary cessation of anticoagulants.
This is a clinical protocol for temporarily stopping oral anticoagulant medications, not a drug itself.
This is a clinical protocol for temporarily stopping oral anticoagulant medications, not a drug itself. Used for Perioperative management of patients on chronic oral anticoagulation, Bridging strategy for patients requiring temporary cessation of anticoagulants.
At a glance
| Generic name | Interruption of oral anticoagulants |
|---|---|
| Sponsor | St. Antonius Hospital |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Interruption of oral anticoagulants refers to a managed clinical intervention where anticoagulant therapy is deliberately paused, typically perioperatively or for specific clinical procedures. This is a therapeutic management strategy rather than a pharmacological agent, designed to balance bleeding risk during procedures against thrombotic risk from interrupted anticoagulation.
Approved indications
- Perioperative management of patients on chronic oral anticoagulation
- Bridging strategy for patients requiring temporary cessation of anticoagulants
Common side effects
- Thromboembolism (stroke, DVT, PE)
- Bleeding complications
Key clinical trials
- Short-term Interruption Versus Continuous Anticoagulation in Colorectal Polypectomy (PHASE4)
- Peri-procedural Management of Direct Oral Anticoagulants for Central VENOus Catheters in CAncer Patients With Venous Thromboembolism or Atrial Fibrillation Pilot Study (NA)
- Perioperative Anticoagulant Use for Surgery Evaluation -Virtual Visit (PAUSE-Virtual)
- DOAC in Chinese Patients With Atrial Fibrillation
- Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation (POPular PAUSE TAVI) (PHASE4)
- Pill-in-the-POCKET Oral Anticoagulation Strategy After AF Catheter Ablation (NA)
- Perioperative Anticoagulant Use for Surgery Evaluation Emergency Registry
- Keeping Oral o Parental AnticoaguLation in the Acute Phase of Cardioembolic Ischemic Stroke
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Interruption of oral anticoagulants CI brief — competitive landscape report
- Interruption of oral anticoagulants updates RSS · CI watch RSS
- St. Antonius Hospital portfolio CI
Frequently asked questions about Interruption of oral anticoagulants
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Related
- Manufacturer: St. Antonius Hospital — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Perioperative management of patients on chronic oral anticoagulation
- Indication: Drugs for Bridging strategy for patients requiring temporary cessation of anticoagulants
- Compare: Interruption of oral anticoagulants vs similar drugs
- Pricing: Interruption of oral anticoagulants cost, discount & access