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Injection of methylprednisolone
Methylprednisolone is a corticosteroid that suppresses the immune system and reduces inflammation by inhibiting pro-inflammatory cytokine production and immune cell activation.
Methylprednisolone is a corticosteroid that suppresses the immune system and reduces inflammation by inhibiting pro-inflammatory cytokine production and immune cell activation. Used for Inflammatory and autoimmune disorders (specific indication in phase 3 trial not specified in provided data).
At a glance
| Generic name | Injection of methylprednisolone |
|---|---|
| Sponsor | Centre Hospitalier Universitaire Dijon |
| Drug class | Corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Immunology |
| Phase | Phase 3 |
Mechanism of action
Methylprednisolone binds to glucocorticoid receptors in the cytoplasm, translocates to the nucleus, and modulates gene transcription to decrease production of inflammatory mediators (IL-1, IL-6, TNF-α) and reduce immune cell proliferation and migration. This broad immunosuppressive and anti-inflammatory action makes it useful across multiple inflammatory and autoimmune conditions.
Approved indications
- Inflammatory and autoimmune disorders (specific indication in phase 3 trial not specified in provided data)
Common side effects
- Hyperglycemia
- Hypertension
- Insomnia
- Mood changes
- Immunosuppression/increased infection risk
- Osteoporosis (with chronic use)
Key clinical trials
- OMT for Adhesive Capsulitis (PHASE4)
- Arthrosemid vs. Steroid for the Management Knee Osteoarthritis (PHASE4)
- A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation (PHASE2, PHASE3)
- Hoffa's Fat Pad Impingement (HFPI) (PHASE4)
- Therapy in the Acute Phase of NMOSD: A Multicenter Prospective Real-World Study (PHASE4)
- The Efficacy and Safety of Biologics (Belimumab/ Telitacicept) Induction Therapy in Proliferative Lupus Nephritis Patients for 6 Months Compared With Mycophenolate Mofetil Treatment (PHASE2)
- Post-operative Methylprednisolone Taper Course for Orthopedic Surgery (PHASE4)
- Combination of Fluoroscopy and Ultrasonography Guidance in Sacroiliac Joint Injections. A Randomised Controlled Trial (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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