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infiltration of corticosteroids
Corticosteroid infiltration delivers anti-inflammatory glucocorticoids directly into affected tissues to suppress local immune responses and reduce inflammation.
Corticosteroid infiltration delivers anti-inflammatory glucocorticoids directly into affected tissues to suppress local immune responses and reduce inflammation. Used for Local inflammation and pain in joints, Soft tissue inflammation, Localized dermatological conditions.
At a glance
| Generic name | infiltration of corticosteroids |
|---|---|
| Sponsor | Centre Hospitalier Departemental Vendee |
| Drug class | Corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Immunology, Rheumatology, Dermatology |
| Phase | FDA-approved |
Mechanism of action
Infiltration (local injection) of corticosteroids provides targeted delivery of glucocorticoids to specific anatomical sites, such as joints, soft tissues, or lesions. The corticosteroids bind to glucocorticoid receptors in local immune cells, suppressing cytokine production, reducing vasodilation, and decreasing inflammatory cell infiltration. This localized approach minimizes systemic exposure while achieving high local concentrations at the site of inflammation.
Approved indications
- Local inflammation and pain in joints
- Soft tissue inflammation
- Localized dermatological conditions
Common side effects
- Local injection site pain or discomfort
- Transient local swelling
- Skin atrophy at injection site
- Systemic corticosteroid effects (with repeated infiltrations)
Key clinical trials
- Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone (PHASE4)
- Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty (NA)
- Percutaneous Electrical Nerve Stimulation As Alternative To Nerve Blocks In Anesthesia, Pain Medicine And Rehabilitation Of Nonspecific Chronic Pain (PHASE4)
- Meniscal INfiltration of Corticosteroid Guided With Ultra Sonography (PHASE3)
- Effects on the Pain of an Infiltration by Acid Hyaluronic Association and Corticoids Versus Only Corticoids in the Rhizarthrosis. (PHASE4)
- Calciying Tendinopathy of the Rotator Cuff: Barbotage Vs Shock Waves (NA)
- 3-month Screening Biopsy to Optimize the Immunosuppression in Renal Transplantation (PHASE3)
- Effectiveness of Percutaneous Pulley Release With Infiltration, Versus Infiltration Alone in Trigger Finders (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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