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Ilaprazole + Amoxicillin
Ilaprazole + Amoxicillin is a Proton pump inhibitor + Beta-lactam antibiotic combination Small molecule drug developed by Il-Yang Pharm. Co., Ltd.. It is currently FDA-approved for Helicobacter pylori eradication in peptic ulcer disease, H. pylori-associated gastritis. Also known as: Ilaprazole, Amoxicillin.
Ilaprazole inhibits gastric acid secretion while amoxicillin kills Helicobacter pylori bacteria, together eradicating H. pylori infection and healing peptic ulcers.
Ilaprazole is a small molecule used in combination with Amoxicillin, a sodium salt of the antibiotic amoxicillin, to treat conditions such as Helicobacter Pylori infection and peptic ulcer hemorrhage. This combination is also being studied for its potential to potentiate drug interactions and for its safety profile when used with other medications.
At a glance
| Generic name | Ilaprazole + Amoxicillin |
|---|---|
| Also known as | Ilaprazole, Amoxicillin |
| Sponsor | Il-Yang Pharm. Co., Ltd. |
| Drug class | Proton pump inhibitor + Beta-lactam antibiotic combination |
| Target | H+/K+-ATPase (ilaprazole); Bacterial cell wall peptidoglycan (amoxicillin) |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Ilaprazole is a proton pump inhibitor that blocks the H+/K+-ATPase enzyme in gastric parietal cells, reducing stomach acid production and creating an environment where amoxicillin can effectively eliminate H. pylori. Amoxicillin is a beta-lactam antibiotic that disrupts bacterial cell wall synthesis. This combination therapy addresses both the acid-related damage and the underlying bacterial infection responsible for most peptic ulcers.
Approved indications
- Helicobacter pylori eradication in peptic ulcer disease
- H. pylori-associated gastritis
Common side effects
- Diarrhea
- Nausea
- Abdominal pain
- Headache
- Rash (amoxicillin-related)
Key clinical trials
- Efficacy and Safety Study of Egg Yolk Antibody in Adjuvant Treatment of Helicobacter Pylori Infection (NA)
- Influence of Oral Hp Infection and Oral Related Factors on Gastric Hp Infection and Eradication Therapy (NA)
- The Efficacy and Safety of Ilaprazole/Doxycycline-based Bismuth-containing Quadruple Therapy on Hp Infected Duodenal Ulcers (PHASE4)
- The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in H.Pylori Patients (PHASE4)
- Ilaprazole for the Treatment and Prevention of Peptic Ulcer Bleeding in Chinese Patients (PHASE3)
- Antimicrobial Susceptibility Testing Guided Triple Therapy in Salvage Helicobacter Pylori Treatment (PHASE4)
- Antimicrobial Susceptibility Testing Guided Antibiotic Selection Strategies in Salvage Helicobacter Pylori Treatment (PHASE4)
- A Study on Eradication Rate of Triple Therapy According to Treatment Period and CYP2C19 Polymorphisms in H.Pylori Patients
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ilaprazole + Amoxicillin CI brief — competitive landscape report
- Ilaprazole + Amoxicillin updates RSS · CI watch RSS
- Il-Yang Pharm. Co., Ltd. portfolio CI
Frequently asked questions about Ilaprazole + Amoxicillin
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Related
- Drug class: All Proton pump inhibitor + Beta-lactam antibiotic combination drugs
- Target: All drugs targeting H+/K+-ATPase (ilaprazole); Bacterial cell wall peptidoglycan (amoxicillin)
- Manufacturer: Il-Yang Pharm. Co., Ltd. — full pipeline
- Therapeutic area: All drugs in Gastroenterology
- Indication: Drugs for Helicobacter pylori eradication in peptic ulcer disease
- Indication: Drugs for H. pylori-associated gastritis
- Also known as: Ilaprazole, Amoxicillin
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing