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IDP-124 Lotion
IDP-124 is a topical lotion formulation combining calcipotriene and betamethasone dipropionate to reduce inflammation and normalize skin cell differentiation in psoriasis.
IDP-124 is a topical lotion formulation combining calcipotriene and betamethasone dipropionate to reduce inflammation and normalize skin cell differentiation in psoriasis. Used for Plaque psoriasis.
At a glance
| Generic name | IDP-124 Lotion |
|---|---|
| Sponsor | Bausch Health Americas, Inc. |
| Drug class | Topical corticosteroid and vitamin D analog combination |
| Target | Vitamin D receptor (VDR) and glucocorticoid receptor (GR) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Calcipotriene is a vitamin D3 analog that regulates keratinocyte proliferation and differentiation, while betamethasone dipropionate is a potent topical corticosteroid that suppresses inflammatory cytokines and immune cell infiltration. Together, these agents work synergistically to reduce erythema, scaling, and plaque formation characteristic of psoriasis.
Approved indications
- Plaque psoriasis
Common side effects
- Application site irritation
- Application site burning
- Skin atrophy (with prolonged use)
Key clinical trials
- Efficacy and Safety of IDP-124 Lotion for the Treatment of Moderate to Severe Atopic Dermatitis in Pediatric and Adult Subjects (301) (PHASE3)
- Efficacy and Safety of IDP-124 Lotion for the Treatment of Moderate to Severe Atopic Dermatitis in Pediatric and Adult Subjects (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- IDP-124 Lotion CI brief — competitive landscape report
- IDP-124 Lotion updates RSS · CI watch RSS
- Bausch Health Americas, Inc. portfolio CI