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ICG (Indocyanine Green)
Indocyanine green is a near-infrared fluorescent dye that emits light when excited by near-infrared wavelengths, enabling real-time visualization of tissues and blood vessels during surgical and diagnostic procedures.
Indocyanine green is a near-infrared fluorescent dye that emits light when excited by near-infrared wavelengths, enabling real-time visualization of tissues and blood vessels during surgical and diagnostic procedures. Used for Intraoperative fluorescence-guided surgery for tumor visualization and margin delineation, Angiography and vascular imaging, Lymph node mapping and sentinel lymph node identification.
At a glance
| Generic name | ICG (Indocyanine Green) |
|---|---|
| Also known as | NDC # 75874-0701-25 |
| Sponsor | Fujian Medical University Union Hospital |
| Drug class | Near-infrared fluorescent imaging agent |
| Modality | Small molecule |
| Therapeutic area | Surgical imaging / Diagnostic imaging |
| Phase | Phase 3 |
Mechanism of action
ICG absorbs light in the near-infrared spectrum (780–820 nm) and fluoresces at approximately 820 nm, allowing deep tissue penetration with minimal autofluorescence. It binds to plasma proteins and is used intraoperatively for fluorescence-guided surgery, angiography, and tissue perfusion assessment. The dye is rapidly cleared hepatically and excreted in bile.
Approved indications
- Intraoperative fluorescence-guided surgery for tumor visualization and margin delineation
- Angiography and vascular imaging
- Lymph node mapping and sentinel lymph node identification
Common side effects
- Anaphylaxis or anaphylactoid reaction
- Rash or urticaria
- Transient hypotension
Key clinical trials
- Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer (PHASE3)
- Indocyanine Green Fluorescence Angiography (ICG-FA) in Revisional Bariatric Surgery (NA)
- Fluorescence Guided Laparoscopic-Endoscopic Cooperative Sentinel Lymph Node Navigation Surgery Strategy for Early Gastric Cancer (NA)
- Real-Time Diagnosis of Life-Threatening Necrotizing Soft Tissue Infections (NSTI) Using Indocyanine Green (ICG) Kinetic Modeling
- Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors (PHASE2)
- Contribution of ICG Angiography in the Detection of Parathyroids and the Prevention of Hypoparathyroidism Post Total Thyroidectomy (PHASE3)
- Acute Cholecystitis Biliary Complications - ICG (NA)
- Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic Disorders
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ICG (Indocyanine Green) CI brief — competitive landscape report
- ICG (Indocyanine Green) updates RSS · CI watch RSS
- Fujian Medical University Union Hospital portfolio CI